Description

Hydroxyfasudil Monohydrochloride is a potent and selective Rho-associated protein kinase (ROCK) inhibitor, representing a key intermediate and active metabolite of the parent compound Fasudil. This high-purity compound is essential for advanced pharmaceutical research and development, particularly in the study of cardiovascular and neurological pathways. It is primarily utilized by research institutions, pharmaceutical developers, and contract manufacturing organizations (CMOs) focused on creating novel therapeutics for conditions such as hypertension, cerebral vasospasm, and other diseases mediated by the ROCK signaling pathway.

Application

• Pharmaceutical Intermediate: Critical synthesis component for the production of advanced ROCK inhibitor drug candidates.
• Biochemical Research: Used as a reference standard and tool compound in enzymatic and cellular assays to study Rho/ROCK signaling mechanisms.
• Preclinical Development: Employed in pharmacokinetic and pharmacodynamic (PK/PD) studies to understand the metabolism and efficacy of Fasudil-related therapeutics.
• Cardiovascular Research: Investigated for its vasodilatory effects and potential in treating pulmonary arterial hypertension and angina.
• Neuropharmacology Studies: Applied in research targeting cerebral ischemia, stroke recovery, and neurodegenerative conditions.
• Reference Standard: Serves as a high-purity calibrant for analytical method development and quality control in pharmaceutical manufacturing.

Basic Information

Product Name	Hydroxyfasudil Monohydrochloride
CAS No.	155558-32-0
Molecular Formula	C14H17N3O2•HCl
Molecular Weight	295.76 g/mol
Synonyms	HA-1100; Hydroxyfasudil HCl; (+)-trans-4-[(1R)-1-Aminoethyl]-N-(4-pyridyl)cyclohexanecarboxamide Monohydrochloride; 1-(5-Isoquinolinesulfonyl)homopiperazine, Hydrochloride; Hydroxyfasudil Hydrochloride; HA 1100; (R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)cyclohexanecarboxamide Monohydrochloride
EINECS	Contact for details

Quality Control

Our Hydroxyfasudil Monohydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and stringent control of residual solvents and impurities. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and development grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.