Description

Ritonavir is a potent and selective inhibitor of the human immunodeficiency virus (HIV) protease enzyme, playing a critical role in antiretroviral therapy. Its primary commercial value lies in its use as a pharmacokinetic enhancer or "booster," significantly increasing the plasma concentrations of other co-administered protease inhibitors to improve therapeutic efficacy. This active pharmaceutical ingredient (API) is essential for manufacturers in the global pharmaceutical industry developing and producing combination therapies for the treatment of HIV-1 infection.

Application

• Active Pharmaceutical Ingredient (API) in antiretroviral combination therapies for HIV-1 infection.
• Key component as a pharmacokinetic enhancer (booster) in fixed-dose combination drugs, such as with lopinavir or other protease inhibitors.
• Manufacturing of solid oral dosage forms, including tablets and capsules.
• Research and development of novel drug formulations and delivery systems.
• Reference standard for analytical testing and quality control in pharmaceutical laboratories.
• Use in clinical trial materials for investigational HIV therapies.
• Production of generic antiviral medications for global health initiatives.

Basic Information

Product Name	Ritonavir
CAS No.	155213-67-5
Molecular Formula	C37H48N6O5S2
Molecular Weight	720.95 g/mol
Synonyms	Norvir; ABT-538; RTV; 5-Thiazolylmethyl [(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-diphenyl-hexan-2-yl]carbamate; Lopinavir/Ritonavir; Thiazolyl Carbamate Derivative ABT-538
EINECS	Contact for details

Quality Control

Our Ritonavir is manufactured under strict quality management systems, targeting compliance with ICH Q7 guidelines and relevant pharmacopoeial standards. Every batch undergoes comprehensive analytical testing, including identity, purity, and impurity profile determination via advanced techniques like HPLC. A detailed Certificate of Analysis (COA), confirming specifications for assay, related substances, residual solvents, and microbial limits, is provided with each shipment to ensure full traceability and regulatory support.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.0% - 102.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH Q3C limits
Microbial Enumeration	Meets Ph. Eur. 2.6.12/ USP <61>

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.