Description

Enantiomer Efavirenz CAS NO 154801-74-8 is the single, optically pure enantiomer of the non-nucleoside reverse transcriptase inhibitor (NNRTI) Efavirenz. This high-purity chiral intermediate is critical for ensuring the efficacy and safety profile of the final active pharmaceutical ingredient (API). It is primarily required by pharmaceutical manufacturers and advanced research institutions engaged in the development and production of antiretroviral therapies, particularly for the treatment of HIV-1 infection.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: As a key chiral building block in the manufacture of the Efavirenz API.
• Pharmaceutical Research & Development: For use in preclinical and clinical studies to investigate enantiomer-specific pharmacokinetics and pharmacodynamics.
• Process Chemistry & Optimization: Serves as a reference standard and starting material for developing and scaling up stereoselective synthesis routes.
• Quality Control & Analytical Standards: Used as a certified reference material (CRM) for HPLC, chiral chromatography, and other analytical methods to ensure batch purity and regulatory compliance.
• Generic Drug Manufacturing: Essential for producers of generic antiretroviral formulations to match the chiral purity of the originator product.

Basic Information

Product Name	Enantiomer Efavirenz
CAS No.	154801-74-8
Molecular Formula	C14H9ClF3NO2
Molecular Weight	315.67 g/mol
Synonyms	(S)-Efavirenz; (-)-Efavirenz; Efavirenz Enantiomer; (4S)-6-Chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-2,4-dihydro-1H-3,1-benzoxazin-2-one; Sustiva Enantiomer (S-Form); DMP 266 Enantiomer; L-743,726 Enantiomer
EINECS	Contact for details

Quality Control

Our Enantiomer Efavirenz is manufactured under strict quality management systems. Each batch is tested to meet high-purity standards typical for pharmaceutical intermediates, with a focus on chiral purity and impurity profile control. Certificates of Analysis (COA) detailing specifications such as enantiomeric excess (ee), assay, and related substances are provided with every shipment to ensure traceability and regulatory compliance for GMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤1.5%
Single Maximum Unknown Impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.