Description

Hemoglobin F-Saskatoon is a specific variant of fetal hemoglobin (HbF) characterized by a point mutation, primarily used as a critical reference standard and research reagent in hematology and clinical diagnostics. This compound is essential for the study of hemoglobinopathies, enabling precise calibration of analytical instruments and validation of diagnostic assays. It is a vital material for pharmaceutical R&D, clinical laboratories, and academic institutions focused on sickle cell disease research and the development of novel therapeutic strategies.

Application

• Diagnostic Standard: Serves as a primary reference material for calibrating HPLC and electrophoresis systems used in newborn screening and hemoglobin variant analysis.
• Clinical Research: Utilized in studies investigating the pathophysiology and treatment monitoring of sickle cell disease and other hemoglobin disorders.
• Biopharmaceutical Development: Acts as a key reagent in the research and quality control of therapies aimed at modulating fetal hemoglobin expression.
• Academic & Method Validation: Employed in university and institutional labs for method development, validation, and comparative studies of hemoglobin variants.
• Quality Control Material: Used by in-vitro diagnostic (IVD) manufacturers as a component in control kits to ensure assay accuracy and reproducibility.

Basic Information

Product Name	Hemoglobin F-Saskatoon
CAS No.	154765-83-0
Molecular Formula	C2952H4664N812O840S16Fe4
Molecular Weight	~64,500 Da (for tetramer)
Synonyms	Hb F-Saskatoon; Hemoglobin F Saskatoon; Fetal Hemoglobin Saskatoon variant; γ-Globin variant Saskatoon; HbF (γ136 Gly→Asp); Gγ 136 Gly→Asp; Hemoglobin F with mutation at γ-136
EINECS	Contact for details

Quality Control

Our Hemoglobin F-Saskatoon is produced and handled under strict quality protocols to ensure batch-to-batch consistency and integrity. Each lot is characterized using advanced analytical techniques including HPLC, mass spectrometry, and electrophoresis to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, physical form, and stability data is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For extended storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	Lyophilized powder
Identification (HPLC)	Conforms to reference standard
Purity (by HPLC)	≥ 95%
Solubility	Soluble in water or buffer
Moisture Content (KF)	≤ 5.0%
Biological Activity	Retains oxygen-binding capacity

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.