Description

Palinavir is a synthetic antiviral compound developed for research into viral replication inhibition and host-cell entry modulation. It serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate in preclinical and early-stage drug development programs. Pharmaceutical R&D laboratories, contract research organizations (CROs), and API manufacturers rely on high-purity Palinavir CAS NO 154612-39-2 for assay validation, mechanism-of-action studies, and formulation stability testing.

Application

• Preclinical antiviral drug discovery targeting RNA virus families (e.g., flaviviruses, coronaviruses)
• Reference standard for HPLC and LC-MS/MS method development and validation
• Lead compound optimization in medicinal chemistry programs focused on protease or polymerase inhibition
• Cell-based assays evaluating viral cytopathic effect (CPE) reduction and plaque inhibition
• Stability-indicating assay development for related nucleoside/nucleotide analogs
• Pharmacokinetic and metabolic profiling studies in hepatic microsome and Caco-2 models
• Crystallization and solid-form screening for polymorph characterization
• GMP-compliant process development support for clinical trial material synthesis

Basic Information

Product Name	Palinavir
CAS No.	154612-39-2
Molecular Formula	C22H28N6O4
Molecular Weight	440.50 g/mol
Synonyms	Palinavir; 154612-39-2; N-(4-((2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-methylpyrimidin-5-yl)benzamide; Benzamide, N-[4-[(2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]-2-methyl-5-pyrimidinyl]-; PAL-154612; Palinavir hydrochloride (salt form); NSC 724932; UNII-7Z6VQ5X1YH
EINECS	Not listed

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches meet stringent specifications for identity, purity, residual solvents, heavy metals, and microbial limits per ICH Q5, Q6A, and Q7 guidelines. Testing includes HPLC purity ≥99.5%, chiral purity >99.0% ee, and full spectral confirmation (IR, 1H-NMR, MS). Available grades include Research Grade, USP Reference Standard Grade, and GMP Intermediate Grade.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8°C under inert atmosphere (nitrogen or argon) due to sensitivity to oxidation. Keep away from moisture and strong acids or organic solvents. Maintain relative humidity below 30% during storage and handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	99.0–101.0%
Related Substances (HPLC)	Single impurity ≤0.3%; Total impurities ≤0.5%
Residual Solvents (GC)	Meets ICH Q3C Class 3 limits
Heavy Metals	≤10 ppm
Water (Karl Fischer)	≤0.5%
Optical Rotation ([α]D²⁵)	–12.5° to –14.5° (c = 1, in methanol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.