Description

Efavirenz CAS NO 154598-52-4 is a potent non-nucleoside reverse transcriptase inhibitor (NNRTI) used in antiretroviral therapy. It is a critical active pharmaceutical ingredient (API) for the treatment of Human Immunodeficiency Virus type 1 (HIV-1) infection. This high-purity compound is essential for pharmaceutical manufacturers producing fixed-dose combination therapies and generic antiviral medications. Its role in first-line treatment regimens underscores its importance in global public health initiatives.

Application

• Antiretroviral Drug Manufacturing: Primary API for the synthesis of HIV-1 medication formulations.
• Fixed-Dose Combination Tablets: Key component in combination therapies with other antiretrovirals like tenofovir and emtricitabine.
• Generic Pharmaceutical Production: Sourcing for manufacturers of bioequivalent generic versions of branded HIV treatments.
• Clinical Research & Development: Used in studies for new HIV treatment protocols and drug delivery systems.
• Pharmaceutical Reference Standards: Serves as a high-purity chemical reference material for quality control laboratories.
• Pre-Formulation Studies: Utilized in R&D for developing new dosage forms, including pediatric formulations.

Basic Information

Product Name	Efavirenz
CAS No.	154598-52-4
Molecular Formula	C14H9ClF3NO2
Molecular Weight	315.67 g/mol
Synonyms	Efavirenz; DMP 266; Sustiva (Brand Name); (4S)-6-Chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-2,4-dihydro-1H-3,1-benzoxazin-2-one; L-743,726; EFV; (+)-Efavirenz
EINECS	Contact for details

Quality Control

Our Efavirenz is manufactured under strict quality management systems, targeting compliance with ICH Q7 guidelines and current Good Manufacturing Practices (cGMP). Each batch undergoes comprehensive analytical testing, including identification, assay, impurity profiling, and residual solvent analysis. A Certificate of Analysis (COA) detailing purity, related substances, and physical characteristics is provided with every shipment to ensure traceability and regulatory compliance for pharmaceutical use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. The container should be kept tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Individual impurity: NMT 0.15% Total impurities: NMT 0.5%
Water Content (KF)	NMT 0.5%
Residue on Ignition	NMT 0.1%
Heavy Metals	NMT 20 ppm
Specific Optical Rotation	Contact for details
Particle Size Distribution	Available upon request

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.