Description

1-Stearoyl-2-15(S)-Hpete-Sn-Glycero-3-Pe is a specialized, high-purity phospholipid derivative, a key intermediate in advanced lipidomics research and pharmaceutical development. This compound is critical for studying the role of oxidized phospholipids in cellular signaling pathways, inflammation, and metabolic processes. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic manufacturers focused on cardiovascular, neurological, and inflammatory disease models.

Application

• Biochemical Research: As a standard or substrate in enzymatic studies, particularly for phospholipase A2 (PLA2) and other lipoxygenase pathway enzymes.
• Lipidomics & Metabolomics: A critical reference compound for the identification and quantification of oxidized phospholipids in complex biological samples using LC-MS/MS.
• Pharmaceutical R&D: Investigation of novel drug targets related to oxidative stress, inflammation (e.g., atherosclerosis), and cell membrane biology.
• Diagnostic Development: Potential use in calibrating assays for biomarkers of oxidative damage and inflammatory diseases.
• Cell Signaling Studies: Probing the biological activity of specific oxidized phospholipid species in receptor-mediated pathways.
• Formulation Science: Research into advanced lipid-based drug delivery systems, such as liposomes and lipid nanoparticles.

Basic Information

Product Name	1-Stearoyl-2-15(S)-Hpete-Sn-Glycero-3-Pe
CAS No.	154436-49-4
Molecular Formula	C44H79O10P
Molecular Weight	799.07 g/mol
Synonyms	1-Stearoyl-2-(15S-hydroperoxyeicosatetraenoyl)-sn-glycero-3-phosphoethanolamine; 15(S)-HPETE-PE; Oxidized Phosphatidylethanolamine; PE(18:0/20:4-15(S)-OOH); 1-Octadecanoyl-2-(15S-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine; 15S-HpETE PE; OxPL; Phospholipid Peroxide Standard
EINECS	Contact for details

Quality Control

Our 1-Stearoyl-2-15(S)-Hpete-Sn-Glycero-3-Pe is manufactured under strict quality protocols to ensure batch-to-batch consistency and high chemical purity, essential for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and stability indicators. We adhere to ISO 9001 quality management standards, and our processes are designed to support research requiring regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen). This product is hygroscopic (moisture-sensitive) and easily oxidized; allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and exposure to air.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (HPLC/MS)	Conforms to structure
Assay (HPLC)	≥ 95%
15(S) Enantiomeric Excess	≥ 98%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Solvent Content (Residual Solvents)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.