Description

13,15-o-Bidesmethylascomycin is a key derivative of the potent immunosuppressant ascomycin, representing a significant intermediate in the synthesis of advanced pharmaceutical compounds. Its value lies in its specific chemical structure, which is crucial for research and development into novel immunomodulatory and anti-inflammatory agents. This product is primarily needed by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions focused on developing next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel immunosuppressant and anti-inflammatory drug candidates.
• Biochemical Research: Used as a reference standard and active probe in studies of immunophilin binding and T-cell activation pathways.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity.
• Process Development: Employed in the scale-up and optimization of synthetic routes for complex macrolide pharmaceuticals.
• Reference Material: Utilized in analytical method development and validation for quality control of related pharmaceutical substances.

Basic Information

Product Name	13,15-o-Bidesmethylascomycin
CAS No.	153781-49-8
Molecular Formula	C42H65NO12
Molecular Weight	775.97 g/mol
Synonyms	13,15-O-Didesmethylascomycin; 13,15-Didesmethylascomycin; 13,15-Di-O-desmethylascomycin; Ascomycin, 13,15-didesmethyl-; (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,8,16,18-Tetrahydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylvinyl]-14,15-dimethoxy-4,10,12,16-tetramethyl-9,26a-epoxy-1H,3H,23H-furo[3,2-h]pyrido[2,1-f][1,2,6]oxadiazacyclotetracosine-2,7,17,19,23(4H,10H)-pentone
EINECS	Contact for details

Quality Control

Our 13,15-o-Bidesmethylascomycin is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.