Description

13-o-Desmethylascomycin is a key chemical intermediate and reference standard derived from the ascomycin family of macrolide compounds. This high-purity compound is valued for its role in pharmaceutical research and development, particularly in the study of immunosuppressive mechanisms and novel therapeutic agents. It is primarily utilized by research institutions, pharmaceutical developers, and fine chemical manufacturers engaged in advanced medicinal chemistry and bioassay development.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel immunosuppressant and anti-inflammatory drug candidates.
• Biochemical Research: Used as a reference standard and tool compound in studies investigating T-cell activation and signal transduction pathways.
• Reference Material: Employed as a high-purity calibrant in analytical methods (e.g., HPLC, LC-MS) for quality control of related pharmaceutical substances.
• Medicinal Chemistry: Provides a structural scaffold for the design and optimization of new chemical entities with targeted biological activity.
• API Development: Acts as a precursor in the development and scale-up processes for active pharmaceutical ingredients (APIs) within the macrolide class.

Basic Information

Product Name	13-o-Desmethylascomycin
CAS No.	153781-48-7
Molecular Formula	C43H69NO12
Molecular Weight	792.0 g/mol
Synonyms	13-O-Desmethylascomycin; 13-Desmethylascomycin; 13-Demethylascomycin; 13-O-Demethylascomycin; Ascomycin, 13-O-desmethyl-; FR-901459, 13-O-desmethyl-; (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-1,14-Dihydroxy-12-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-(2-propen-1-yl)-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone
EINECS	Contact for details

Quality Control

Our 13-o-Desmethylascomycin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.