Description

Tricyclic Cyclosporin A is a chemically modified derivative of the potent immunosuppressive agent Cyclosporin A. This tricyclic analog is of significant interest in pharmaceutical research for its potential to offer altered pharmacokinetic profiles and biological activity. It serves as a critical intermediate and reference standard for scientists developing novel therapeutics. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in immunology, organ transplantation research, and the development of new immunosuppressive drugs.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate in the synthesis of novel Cyclosporin derivatives with targeted therapeutic properties.
• Immunology Studies: Used as a reference compound to investigate structure-activity relationships (SAR) and mechanisms of immunosuppression.
• Bioactive Compound Library: A valuable component in high-throughput screening libraries for drug discovery programs.
• Analytical Reference Standard: Employed as a certified reference material (CRM) in HPLC, LC-MS, and NMR for quality control and method validation.
• Preclinical Development: Utilized in in vitro and in vivo studies to assess the efficacy and toxicity profiles of new immunosuppressive candidates.

Basic Information

Product Name	Tricyclic Cyclosporin A
CAS No.	153475-57-1
Molecular Formula	C62H111N11O12
Molecular Weight	1202.6 g/mol
Synonyms	Cyclosporin A Tricyclic Derivative; [D-Ser]8-(L-2-aminobutyryl)1-Cyclosporin A; Cyclosporin A, Tricyclic; Cyclosporin A Tricyclic Analog; Tricyclic CsA; Cyclosporin Tricyclic; CsA Tricyclic Derivative
EINECS	Contact for details

Quality Control

Our Tricyclic Cyclosporin A is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade standards. Specifications are designed to meet the rigorous demands of pharmaceutical R&D and analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.