Description

(S)-4-Chlorokynurenine is a high-purity, enantiomerically pure derivative of the kynurenine pathway, specifically designed for advanced research and development applications. This compound serves as a critical intermediate and reference standard in the study of neurological pathways and glutamatergic system modulation. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and fine chemical manufacturers focused on neuroscience and metabolic research. The product is supplied with a commitment to stringent quality control to ensure reliable and reproducible results in sensitive applications.

Application

• Pharmaceutical Research & Development: Key intermediate in the synthesis of novel neuroprotective agents and NMDA receptor modulators.
• Neuroscience Studies: Used as a reference standard and tool compound to investigate the kynurenine pathway's role in neurological disorders.
• Metabolite Analysis: Serves as a calibrated standard in LC-MS and HPLC methods for quantifying kynurenine pathway metabolites in biological samples.
• Biochemical Assay Development: Employed in high-throughput screening (HTS) assays to identify compounds that interact with specific enzymes in the tryptophan degradation pathway.
• Preclinical Studies: Utilized in animal model research to study the effects of pathway modulation on disease states.
• Fine Chemical Synthesis: Acts as a chiral building block for the preparation of more complex, biologically active molecules.

Basic Information

Product Name	(S)-4-Chlorokynurenine
CAS No.	153152-32-0
Molecular Formula	C10H11ClN2O3
Molecular Weight	242.66 g/mol
Synonyms	(S)-2-Amino-4-(4-chlorobenzoyl)butanoic acid; (S)-4-Chloro-DL-kynurenine; (2S)-2-Amino-4-[(4-chlorophenyl)carbonyl]butanoic acid; L-4-Chlorokynurenine; 4-Cl-KYN; (S)-4-Cl-KYN; 4-Chloro-L-kynurenine; 4-Chlorokynurenine, (S)-
EINECS	Contact for details

Quality Control

Every batch of (S)-4-Chlorokynurenine is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality assurance protocols are designed to meet the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC), chiral purity, and impurity profiles is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.