Description

Dl-Valine-1-13C CAS NO 152840-81-8 is a stable isotope-labeled analog of the essential amino acid valine, where the carbon atom at the 1-position is enriched with the 13C isotope. This precise labeling makes it an indispensable tool for advanced research requiring metabolic pathway tracing, quantitative proteomics, and internal standardization in mass spectrometry. It is primarily utilized by scientists and manufacturers in the pharmaceutical, biotechnology, and academic research sectors for drug development, biomarker discovery, and detailed biochemical studies.

Application

• Internal Standard for Mass Spectrometry (MS): Used as a quantitative reference standard in LC-MS and GC-MS analyses for accurate measurement of endogenous valine and related metabolites in complex biological samples.
• Metabolic Flux Analysis (MFA): Enables the tracing of carbon flow through metabolic networks in cell cultures, tissues, or whole organisms to study disease mechanisms and optimize bioproduction processes.
• Proteomics & Stable Isotope Labeling by Amino acids in Cell culture (SILAC): Incorporated into proteins during cell growth to facilitate accurate, multiplexed protein quantification and turnover studies.
• Pharmaceutical Research & Drug Metabolism: Employed in pharmacokinetic (PK) and absorption, distribution, metabolism, and excretion (ADME) studies to track the fate of drug compounds and their metabolites.
• Nutritional & Clinical Research: Serves as a tracer to investigate protein metabolism, amino acid requirements, and metabolic disorders in human and animal studies.
• NMR Spectroscopy: Provides enhanced sensitivity and resolution in nuclear magnetic resonance (NMR) studies for structural elucidation and dynamic analysis of biomolecules.

Basic Information

Product Name	Dl-Valine-1-13C
CAS No.	152840-81-8
Molecular Formula	C413CH11NO2
Molecular Weight	118.14 g/mol
Synonyms	(RS)-2-Amino-3-methylbutanoic-1-13C acid; DL-Valine-1-13C; (±)-Valine-1-13C; Valine-1-13C (racemic); 2-Azaniumyl-3-methylbutanoate-1-13C; 13C Labeled DL-Valine; Racemic Valine-1-13C; UNII-Contact for details
EINECS	Contact for details

Quality Control

Our Dl-Valine-1-13C is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR and mass spectrometry, to confirm isotopic enrichment (typically >99 atom % 13C) and chemical purity. Certificates of Analysis (COA) detailing specific results for assay, isotopic purity, and related substances are provided and available upon request to ensure compliance with your research and development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment (MS)	≥99 atom % 13C
Chemical Purity (NMR)	≥98%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.