Description

Uridine 5'-Diphosphoglucose-[Glucose-1-3H] is a high-specific-activity, tritium-labeled nucleotide sugar derivative essential for biochemical research. This compound serves as a critical radiolabeled tracer for studying enzymatic pathways, particularly glycosyltransferase reactions involved in glycoprotein and glycolipid biosynthesis. It is primarily utilized by researchers in pharmaceutical R&D, academic biochemistry laboratories, and biotechnology companies focused on carbohydrate metabolism and drug discovery.

Application

• Enzymology Studies: As a radiolabeled substrate for kinetic analysis and characterization of glycosyltransferases, including glucosyltransferases and galactosyltransferases.
• Metabolic Pathway Tracing: To investigate and quantify the biosynthesis of complex carbohydrates, glycoproteins, and proteoglycans in cell-free systems and cellular models.
• Drug Discovery Screening: Used in high-throughput assays to identify and evaluate inhibitors of carbohydrate-processing enzymes for therapeutic development in areas like oncology and infectious diseases.
• Biochemical Synthesis Monitoring: To track the incorporation of glucose moieties in the enzymatic synthesis of defined oligosaccharides and other glycoconjugates.
• Diagnostic Kit Development: As a key component in the development of research-grade diagnostic assays for enzyme deficiency disorders related to carbohydrate metabolism.

Basic Information

Product Name	Uridine 5'-Diphosphoglucose-[Glucose-1-3H]
CAS No.	152697-45-5
Molecular Formula	C15H24N2O17P2 (³H labeled)
Molecular Weight	566.31 g/mol (unlabeled)
Synonyms	UDP-[glucose-1-³H]; UDP-Glc-[1-³H]; Uridine diphosphate glucose tritiated; 1-³H-UDP-glucose; UDP-α-D-[1-³H]glucopyranose; Uridine 5'-(α-D-glucopyranosyl diphosphate) [1-³H]; UDP-α-D-Glucose (tritium labeled)
EINECS	Contact for details

Quality Control

Every batch of Uridine 5'-Diphosphoglucose-[Glucose-1-3H] is manufactured and tested to meet stringent research-grade specifications. Our quality assurance includes verification of radiochemical purity and specific activity using validated analytical methods such as HPLC and liquid scintillation counting. A comprehensive Certificate of Analysis (COA), detailing purity, concentration, and solvent information, is provided with each shipment to ensure traceability and reproducibility for your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at or below -20°C in the original solvent as supplied. Avoid repeated freeze-thaw cycles. Handle and dispose of in accordance with all applicable local, national, and international regulations for radioactive materials.

Specification

Item	Specification
Appearance	Clear solution
Identification (HPLC)	Conforms to reference standard
Specific Activity	10-40 Ci/mmol (Contact for exact value)
Radiochemical Purity (HPLC)	≥ 95%
Chemical Purity (HPLC)	≥ 98%
Concentration	1 mCi/mL (in aqueous ethanol)
Solvent	Ethanol:Water (7:3)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.