Description

Dl-Propranolol-[4-3H] Hydrochloride is a tritium-labeled form of the non-selective β-adrenergic receptor antagonist, propranolol. This radiolabeled compound is an essential tool for conducting advanced pharmacokinetic, metabolic, and receptor-binding studies in biomedical research. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in cardiovascular and neurological research, where precise tracing of drug distribution and mechanism of action is required.

Application

• Pharmacokinetic and ADME Studies: Used as a radiotracer to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of propranolol in preclinical models.
• Receptor Binding Assays: Critical for in vitro and ex vivo studies to quantify β-adrenergic receptor occupancy, affinity (Kd), and density (Bmax).
• Metabolic Pathway Analysis: Enables the identification and quantification of propranolol metabolites in biological matrices using radio-HPLC or LC-MS techniques.
• Drug Transport Research: Applied in studies to understand blood-brain barrier penetration and tissue-specific uptake of β-blockers.
• Autoradiography: Facilitates the visual localization of drug binding sites in tissue sections for anatomical mapping of receptor targets.
• Quality Control Reference Standard: Serves as an internal standard in analytical method development and validation for propranolol quantification.

Basic Information

Product Name	Dl-Propranolol-[4-3H] Hydrochloride
CAS No.	152558-63-9
Molecular Formula	C16H22ClNO2 • 3H (Tritium labeled at the 4-position)
Molecular Weight	~295.8 g/mol (base compound) + label
Synonyms	1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol-[4-3H] Hydrochloride; (±)-Propranolol-[4-3H] HCl; DL-Propranolol, tritiated; 3H-Propranolol Hydrochloride; ICI 45520 (tritiated); Propra-[4-3H]; Tritium Labeled Propranolol HCl; [4-3H]-Propranolol Hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Dl-Propranolol-[4-3H] Hydrochloride is manufactured and analyzed under strict quality systems. The product undergoes rigorous testing to ensure compliance with high-purity research-grade standards, with key parameters including radiochemical purity, specific activity, and chemical identity verified. A comprehensive Certificate of Analysis (COA) detailing the analytical results, including HPLC radiochromatograms, is provided with each shipment to guarantee traceability and reproducibility for your critical research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term stability, it is recommended to store the material desiccated. Users must handle this radioactive material in accordance with all applicable local and national radiation safety regulations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	Contact for details (Ci/mmol range)
Chemical Purity (HPLC)	≥ 98%
Solvent (for solution forms)	Ethanol, specified concentration

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.