Description

1-[3-(Trifluoromethyl)Phenyl]Cyclobutane-1-Carboxylic Acid is a high-value fluorinated organic building block, essential for introducing the cyclobutyl and trifluoromethylphenyl pharmacophores into advanced molecular structures. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and binding affinity. It is primarily sought by pharmaceutical R&D laboratories, agrochemical innovators, and specialty chemical manufacturers for creating next-generation therapeutic and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon in the development of small molecule drugs targeting central nervous system (CNS) disorders, inflammatory diseases, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Incorporated into monomers for the development of specialty polymers with unique optical or electronic properties.
• Chemical Biology Probes: Utilized in the design of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up campaigns in CDMO (Contract Development and Manufacturing Organization) facilities.

Basic Information

Product Name	1-[3-(Trifluoromethyl)Phenyl]Cyclobutane-1-Carboxylic Acid
CAS No.	151157-58-3
Molecular Formula	C12H11F3O2
Molecular Weight	244.21 g/mol
Synonyms	3-(Trifluoromethyl)cyclobutanecarboxylic acid, phenyl-; 1-[3-(Trifluoromethyl)phenyl]cyclobutanecarboxylic acid; α-Phenyl-3-(trifluoromethyl)cyclobutanecarboxylic acid; Cyclobutanecarboxylic acid, 1-[3-(trifluoromethyl)phenyl]-; 151157-58-3; 1-(3-(Trifluoromethyl)phenyl)cyclobutane-1-carboxylic acid; 1-(3-Trifluoromethylphenyl)cyclobutanecarboxylic acid
EINECS	Contact for details

Quality Control

Every batch of 1-[3-(Trifluoromethyl)Phenyl]Cyclobutane-1-Carboxylic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.