Description

1-[4-(Trifluoromethoxy)Phenyl]Cyclobutanecarboxylic Acid is a high-value, synthetically versatile organic building block featuring a cyclobutane core and a trifluoromethoxy-substituted aromatic ring. This unique structure makes it a critical intermediate for the development of advanced pharmaceuticals and agrochemicals, where its scaffold can impart desirable metabolic stability and bioavailability. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for synthesizing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the trifluoromethoxy group for enhanced biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and organometallic chemistry.
• Material Science Research: Employed in the development of organic electronic materials and liquid crystals due to its rigid, aromatic structure.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.
• Academic and Industrial R&D: Used in exploratory chemistry to develop new synthetic methodologies and novel compound libraries.

Basic Information

Product Name	1-[4-(Trifluoromethoxy)Phenyl]Cyclobutanecarboxylic Acid
CAS No.	151157-53-8
Molecular Formula	C12H11F3O3
Molecular Weight	260.21 g/mol
Synonyms	4-(Trifluoromethoxy)phenylcyclobutanecarboxylic Acid; 1-[4-(Trifluoromethoxy)phenyl]cyclobutanecarboxylic acid; Cyclobutanecarboxylic acid, 1-[4-(trifluoromethoxy)phenyl]-; 151157-53-8; α-(4-(Trifluoromethoxy)phenyl)cyclobutanecarboxylic Acid; 4-(Trifluoromethoxy)benzenecarboxylic acid cyclobutyl ester (related); TFMP-CBA (abbreviation)
EINECS	Contact for details

Quality Control

Our 1-[4-(Trifluoromethoxy)Phenyl]Cyclobutanecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent identity. Certificates of Analysis (COA) with full traceability are provided for every shipment, confirming compliance with customer specifications and industry standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.