Description

1-(2-Trifluoromethylphenyl)Cyclobutanecarboxylic Acid is a high-purity fluorinated organic building block of significant interest in advanced chemical synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where the trifluoromethylphenyl moiety imparts desirable metabolic stability and lipophilicity. It is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors engaged in cutting-edge R&D and scale-up production.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides, leveraging the biological activity of the fluorinated aromatic system.
• Ligand and Catalyst Development: Serves as a building block for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty polymers and advanced organic materials with unique electronic or surface properties.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	1-(2-Trifluoromethylphenyl)Cyclobutanecarboxylic Acid
CAS No.	151157-52-7
Molecular Formula	C12H11F3O2
Molecular Weight	244.21 g/mol
Synonyms	2-(Trifluoromethyl)benzenepropanoic acid, α,α-didehydro-γ,γ-dimethyl-γ-lactone; 1-[2-(Trifluoromethyl)phenyl]cyclobutanecarboxylic acid; Cyclobutanecarboxylic acid, 1-[2-(trifluoromethyl)phenyl]-; 1-(2-Trifluoromethylphenyl)cyclobutanecarboxylic acid; 2-(Trifluoromethyl)phenyl cyclobutanecarboxylate (precursor form); α-(2-Trifluoromethylphenyl)cyclobutanecarboxylic acid
EINECS	Contact for details

Quality Control

Our 1-(2-Trifluoromethylphenyl)Cyclobutanecarboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent batch-to-batch reliability essential for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.