Description

1-(4-Fluorophenyl)Cyclobutanecarboxylic Acid is a high-value fluorinated cyclobutane derivative, serving as a critical building block in modern synthetic organic chemistry. Its unique structure, combining a fluorinated aromatic ring with a strained cyclobutane carboxylic acid, makes it an essential intermediate for developing novel active pharmaceutical ingredients (APIs) and advanced materials. This compound is primarily sought by research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures with targeted properties.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Research: Used in the development of new-generation herbicides and pesticides, where the fluorine atom and rigid cyclobutane ring can enhance biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands or metal-organic frameworks (MOFs) in asymmetric catalysis and material science applications.
• Polymer & Material Science: Incorporated as a monomer or modifier to create specialty polymers with unique thermal, optical, or mechanical properties.
• Chemical Biology Probe Synthesis: Utilized to build molecular probes for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects at various scales.

Basic Information

Product Name	1-(4-Fluorophenyl)Cyclobutanecarboxylic Acid
CAS No.	151157-46-9
Molecular Formula	C11H11FO2
Molecular Weight	194.20 g/mol
Synonyms	4-Fluorophenylcyclobutanecarboxylic Acid; 1-(4-Fluorophenyl)cyclobutane-1-carboxylic acid; 1-(p-Fluorophenyl)cyclobutanecarboxylic Acid; Cyclobutanecarboxylic acid, 1-(4-fluorophenyl)-; 151157-46-9; p-Fluorophenylcyclobutanecarboxylic Acid; 4-Fluorophenyl-1-cyclobutanecarboxylic Acid
EINECS	Contact for details

Quality Control

Our 1-(4-Fluorophenyl)Cyclobutanecarboxylic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications in GMP (Good Manufacturing Practice) environments for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.