Description

2,3,5-Trifluoro-4-Pyrrolidin-1-Ylbenzoic Acid is a high-value fluorinated pyrrolidine derivative, serving as a critical building block in modern synthetic chemistry. Its unique structure, featuring a benzoic acid core with strategic fluorine substitution and a pyrrolidine moiety, makes it indispensable for creating novel compounds with enhanced biological activity and physicochemical properties. This advanced intermediate is primarily sought by research and development teams in the pharmaceutical and agrochemical sectors for drug discovery and the synthesis of active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, oncology, and anti-infective agents.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where the fluorine atoms and heterocyclic structure can improve efficacy, selectivity, and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for designing specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs) due to its chelating potential and structural rigidity.
• Material Science: Incorporated into the synthesis of specialty polymers and advanced organic electronic materials to modify solubility, thermal stability, and electronic properties.
• Chemical Biology Probe Synthesis: Utilized as a scaffold for creating fluorescent tags, enzyme inhibitors, and other molecular probes for biochemical and diagnostic research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and small-scale cGMP batches for clinical trials.

Basic Information

Product Name	2,3,5-Trifluoro-4-Pyrrolidin-1-Ylbenzoic Acid
CAS No.	150660-42-7
Molecular Formula	C11H10F3NO2
Molecular Weight	245.20 g/mol
Synonyms	4-(Pyrrolidin-1-yl)-2,3,5-trifluorobenzoic Acid; 2,3,5-Trifluoro-4-(1-pyrrolidinyl)benzoic Acid; 2,3,5-Trifluoro-4-pyrrolidin-1-yl-benzoic Acid; 150660-42-7; Benzoic acid, 2,3,5-trifluoro-4-(1-pyrrolidinyl)-; 4-Pyrrolidino-2,3,5-trifluorobenzoic Acid
EINECS	Contact for details

Quality Control

Our 2,3,5-Trifluoro-4-Pyrrolidin-1-Ylbenzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our quality commitment supports applications in regulated environments, including cGMP for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.