Description

(R,R)-2,2'-Methylenebis(4-Phenyl-2-Oxazoline) is a high-value, chiral bis(oxazoline) ligand widely used in asymmetric synthesis. Its primary value lies in its ability to induce high enantioselectivity in metal-catalyzed reactions, which is critical for producing single-enantiomer intermediates in the pharmaceutical and fine chemical industries. This product is essential for research chemists and process development scientists working on the synthesis of chiral active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• As a chiral ligand for asymmetric cyclopropanation, Diels-Alder, and aldol reactions.
• Key component in enantioselective catalysis for the synthesis of pharmaceutical intermediates.
• Used in the development of chiral catalysts for academic and industrial research.
• Employed in asymmetric alkylation and conjugate addition reactions.
• Facilitates the production of optically pure compounds for agrochemical and material science applications.
• Critical for methodology development in organic and medicinal chemistry.

Basic Information

Item	Details
Product Name	(R,R)-2,2'-Methylenebis(4-Phenyl-2-Oxazoline)
CAS No.	150639-34-2
Molecular Formula	C21H20N2O2
Molecular Weight	332.40 g/mol
Synonyms	(R,R)-Methylenebis(4-phenyl-2-oxazoline); (4R,4'R)-2,2'-Methylenebis(4-phenyl-4,5-dihydrooxazole); (R,R)-MBPO; (R,R)-Bis(4-phenyl-2-oxazolinyl)methane; (R,R)-2,2'-(Methylenebis(4-phenyl-2-oxazoline)); (R,R)-Bisoxazoline Ligand; (R,R)-BOX Ligand Derivative
EINECS	Contact for details

Quality Control

Our (R,R)-2,2'-Methylenebis(4-Phenyl-2-Oxazoline) is produced under strict quality management systems to ensure batch-to-batch consistency and high chiral purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC, to confirm identity and assay. A Certificate of Analysis (COA) detailing purity, enantiomeric excess, and other critical parameters is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.