Description

5-Fluoro Cytosine o-β-D-Glucuronide is a specialized biochemical conjugate, combining the nucleobase analog 5-fluorocytosine with a glucuronic acid moiety. This molecular design is critical for creating targeted prodrugs and diagnostic agents, offering enhanced solubility and specific metabolic activation. It is primarily utilized by pharmaceutical researchers and diagnostic developers in the fields of oncology, antiviral therapy, and molecular imaging.

Application

• Prodrug Development: Serves as a key intermediate in the synthesis of enzyme-activated prodrugs for targeted cancer therapies, such as those used in Antibody-Directed Enzyme Prodrug Therapy (ADEPT).
• Diagnostic Agent Synthesis: Used in the preparation of contrast agents and probes for molecular imaging techniques, including positron emission tomography (PET).
• Antiviral Research: Acts as a precursor for novel antiviral compounds, leveraging the metabolic pathway of glucuronidation for selective drug delivery.
• Biochemical Tool: Employed in enzymatic studies to investigate glucuronidation processes, substrate specificity, and enzyme kinetics in vitro.
• Reference Standard: Provides a high-purity compound for use as a calibration standard in analytical method development and quality control laboratories.

Basic Information

Product Name	5-Fluoro Cytosine o-β-D-Glucuronide
CAS No.	150494-26-1
Molecular Formula	C11H14FN3O7
Molecular Weight	319.25 g/mol
Synonyms	5-Fluorocytosine β-D-Glucuronide; 5-FC-Glucuronide; 1-(β-D-Glucopyranosyluronic acid)-5-fluorocytosine; 5-Fluorocytosine 1-(β-D-glucopyranosiduronic acid); 5-Fluorocytosine O-β-D-Glucuronide; 5-Fluorocytosine glucuronide; FCG; 5-FC-GA
EINECS	Contact for details

Quality Control

Our 5-Fluoro Cytosine o-β-D-Glucuronide is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant cGMP guidelines for the production of pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.