Description

Emivirine is a potent and selective non-nucleoside reverse transcriptase inhibitor (NNRTI) with significant antiviral activity. This compound is a key intermediate in the research and development of novel antiretroviral therapies targeting HIV-1. It is essential for pharmaceutical R&D laboratories and manufacturers focused on antiviral drug discovery and production. The material is supplied as a high-purity chemical entity to support critical development and scale-up processes.

Application

• Primary use as a critical pharmaceutical intermediate in the synthesis of advanced antiretroviral drugs.
• Active pharmaceutical ingredient (API) research and development for HIV-1 treatment regimens.
• Biochemical tool for virology and pharmacology studies investigating NNRTI mechanisms of action.
• Reference standard for analytical method development and quality control in pharmaceutical manufacturing.
• Starting material for the preparation of derivative compounds to explore new structure-activity relationships.
• Component in preclinical and clinical trial materials for antiviral therapeutic candidates.

Basic Information

Product Name	Emivirine
CAS No.	149950-60-7
Molecular Formula	C20H21N5O3S
Molecular Weight	411.48 g/mol
Synonyms	MKC-442; (+)-MKC 442; (+)-6-Benzyl-1-(ethoxymethyl)-5-isopropyluracil; 6-Benzyl-1-(ethoxymethyl)-5-(1-methylethyl)-2,4(1H,3H)-pyrimidinedione; 1-(Ethoxymethyl)-6-benzyl-5-isopropyluracil; (+)-6-Benzyl-1-(ethoxymethyl)-5-isopropyl-1H-pyrimidine-2,4-dione; 5-Isopropyl-6-benzyl-1-(ethoxymethyl)uracil; (+)-6-Benzyl-1-(ethoxymethyl)-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione
EINECS	Contact for details

Quality Control

Our Emivirine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identity confirmation by spectroscopic methods, to ensure it meets stringent pharmaceutical-grade specifications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed-upon specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.