Description

4-Bromo-2-Fluorocinnamic Acid is a halogenated cinnamic acid derivative that serves as a versatile and critical building block in advanced organic synthesis. Its molecular structure, featuring both bromine and fluorine substituents, makes it a valuable precursor for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the halogen atoms contribute to biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for synthesizing fluorinated organic electronic materials, essential for displays and lighting technologies.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create complex biaryl structures.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological processes.
• Polymer & Material Science: Acts as a monomer or functionalization agent for creating specialty polymers with specific optical or chemical resistance properties.

Basic Information

Product Name	4-Bromo-2-Fluorocinnamic Acid
CAS No.	149947-19-3
Molecular Formula	C9H6BrFO2
Molecular Weight	245.05 g/mol
Synonyms	(E)-3-(4-Bromo-2-fluorophenyl)acrylic acid; 4-Bromo-2-fluorocinnamic acid; 2-Fluoro-4-bromocinnamic acid; trans-4-Bromo-2-fluorocinnamic acid; (E)-3-(4-Bromo-2-fluorophenyl)-2-propenoic acid; 3-(4-Bromo-2-fluorophenyl)prop-2-enoic acid; 4-Bromo-2-fluoro-trans-cinnamic acid; 4-Br-2-F-CA
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Fluorocinnamic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent chemical identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 10 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.