Description

Saquinavir Mesylate CAS NO 149845-06-7 is the mesylate salt form of saquinavir, a potent and selective inhibitor of the human immunodeficiency virus (HIV) protease enzyme. This active pharmaceutical ingredient (API) is critical for the formulation of high-efficacy antiviral medications used in combination therapy. It is essential for pharmaceutical manufacturers and research institutions developing treatments for HIV-1 and HIV-2 infections, ensuring therapeutic efficacy and patient safety.

Application

• Pharmaceutical API: Primary use as the active ingredient in antiretroviral drug formulations for the treatment of HIV/AIDS.
• Protease Inhibitor Drugs: Key component in Highly Active Antiretroviral Therapy (HAART) regimens to inhibit viral replication.
• Research & Development: Used in biochemical and virological studies to understand HIV protease mechanisms and resistance profiles.
• Drug Product Manufacturing: Serves as the core raw material for the production of oral solid dosage forms, such as capsules and tablets.
• Reference Standard: Employed as a certified reference material in analytical laboratories for quality control and method validation.
• Preclinical Studies: Utilized in pharmacokinetic, pharmacodynamic, and toxicology research for new drug development.

Basic Information

Product Name	Saquinavir Mesylate
CAS No.	149845-06-7
Molecular Formula	C38H50N6O5 • CH4O3S
Molecular Weight	766.94 g/mol
Synonyms	Saquinavir Methanesulfonate; Ro 31-8959/003; Invirase (brand name component); HIV Protease Inhibitor; (2S)-N-[(2S,3R)-4-[(3S)-3-(tert-Butylcarbamoyl)-decahydroisoquinolin-2-yl]-3-hydroxy-1-phenylbutan-2-yl]-2-(quinolin-2-ylformamido)butanediamide methanesulfonate
EINECS	Contact for details

Quality Control

Our Saquinavir Mesylate is manufactured under strict quality management systems. It undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical use, including identification, assay, impurity profiling, and residual solvent analysis. Certificates of Analysis (COA) are provided with each batch, detailing compliance with relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Sulfated Ash	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.