Description

[(2S,5S)-5-(6-Methylaminopurin-9-Yl)-1,3-Oxathiolan-2-Yl]Methanol CAS NO 149819-63-6 is a high-purity nucleoside analog, a key chiral intermediate in advanced pharmaceutical synthesis. This compound is valued for its role in the development of novel antiviral and anticancer therapeutics, where precise stereochemistry is critical for biological activity. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of nucleoside-based drugs, process chemistry, and custom synthesis projects.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel antiviral and anticancer nucleoside analogs.
• Antiviral Drug Research: Used in the research and development of next-generation therapeutics targeting viral polymerases.
• Process Chemistry & Scale-up: Serves as a key starting material for process optimization and the commercial-scale manufacturing of active pharmaceutical ingredients (APIs).
• Biochemical Research: Employed in enzymatic studies and as a substrate or inhibitor in biochemical assays to study nucleoside metabolism.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of specialized compounds and reference standards.
• Academic Research: Utilized in university and institutional labs for medicinal chemistry programs and stereochemical studies.

Basic Information

Product Name	[(2S,5S)-5-(6-Methylaminopurin-9-Yl)-1,3-Oxathiolan-2-Yl]Methanol
CAS No.	149819-63-6
Molecular Formula	C10H13N5O2S
Molecular Weight	267.31 g/mol
Synonyms	(-)-2'-Deoxy-3'-thia-6-N-methyladenosine; 2'-Deoxy-3'-thia-N6-methyladenosine; 3TC-N6-Me-Adenosine; Lamivudine N6-Methyladenosine Derivative; (2S,5S)-5-(6-(Methylamino)-9H-purin-9-yl)-1,3-oxathiolan-2-yl)methanol; 6-N-Methyl-3'-thia-2',3'-dideoxyadenosine; β-L-2',3'-Dideoxy-3'-thia-6-N-methyladenosine
EINECS	Contact for details

Quality Control

Our [(2S,5S)-5-(6-Methylaminopurin-9-Yl)-1,3-Oxathiolan-2-Yl]Methanol is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for research and pharmaceutical development. We provide comprehensive analytical data, including HPLC purity, chiral purity, and identification by spectroscopic methods. Certificates of Analysis (COA) detailing all specifications and test results are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (2S,5S isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.