Description

2,4(1H,3H)-Pyrimidinedione, 1-[2-(Hydroxymethyl)-1,3-Oxathiolan-5-Yl]- 5-Iodo-, (2S-Trans)- is a high-purity nucleoside analogue derivative of significant interest in advanced pharmaceutical research and development. This compound matters as a key synthetic intermediate or reference standard for the development of novel antiviral and anticancer therapeutics. It is primarily needed by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions engaged in the synthesis and study of modified nucleosides. The precise stereochemistry and functional groups make it a valuable building block for probing biological mechanisms and developing targeted drug candidates.

Application

• Pharmaceutical Intermediate: Critical building block in the synthetic pathway for novel antiviral and anticancer nucleoside analogues.
• Biochemical Research: Used as a reference standard or probe in enzymatic studies, metabolic pathway analysis, and mechanism of action investigations.
• Antiviral Drug Development: Serves as a precursor or active pharmaceutical ingredient (API) intermediate for compounds targeting viral polymerases.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of therapeutic candidates.
• Process Chemistry: Used in scale-up and optimization studies for the commercial manufacturing of complex active molecules.
• Analytical Standard: Provides a high-purity benchmark for quality control (QC) and analytical method development (e.g., HPLC, LC-MS) in pharmaceutical production.

Basic Information

Item	Details
Product Name	2,4(1H,3H)-Pyrimidinedione, 1-[2-(Hydroxymethyl)-1,3-Oxathiolan-5-Yl]- 5-Iodo-, (2S-Trans)-
CAS No.	149819-50-1
Molecular Formula	C8H9IN2O4S
Molecular Weight	356.14 g/mol
Synonyms	5-Iodo-1-[(2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidine-2,4(1H,3H)-dione; 5-Iodo-1-[(2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]uracil; 5-Iodo-2'-deoxy-3'-thiacytidine; 5-Iodo-3TC; 5-Iodo-Lamivudine Impurity; 5-Iodo-BCH-189; (2'R,5'S)-5-Iodo-1-[2-(hydroxymethyl)oxathiolan-5-yl]cytosine; 5-Iodo-(-)-2'-Deoxy-3'-thiacytidine
EINECS	Contact for details

Quality Control

Our 2,4(1H,3H)-Pyrimidinedione, 1-[2-(Hydroxymethyl)-1,3-Oxathiolan-5-Yl]- 5-Iodo-, (2S-Trans)- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Products undergo rigorous analytical testing, including HPLC for assay and related substances, chiral purity verification, and identity confirmation via spectroscopic methods. Certificates of Analysis (COA) detailing all specifications and test results are provided with each shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere to prevent potential degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (2S,5R isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.