Description

Sacubitril Sodium is the sodium salt form of sacubitril, a key pharmaceutical intermediate and active ingredient. This compound is of critical importance as a neprilysin inhibitor and is a primary component in the combination drug sacubitril/valsartan, used to treat chronic heart failure. It is essential for pharmaceutical manufacturers and research institutions engaged in cardiovascular drug development and production. The material is supplied under stringent quality control to ensure consistency and reliability for sensitive formulation processes.

Application

• Active Pharmaceutical Ingredient (API) in the synthesis of sacubitril/valsartan combination drugs.
• Pharmaceutical Intermediate for advanced cardiovascular therapeutics.
• Neprilysin Inhibitor Research in biochemical and pharmacological studies.
• Reference Standard for quality control and analytical method development in pharmaceutical laboratories.
• Formulation Development for solid dosage forms such as tablets.
• Contract Manufacturing for generic and innovative drug producers.

Basic Information

Product Name	Sacubitril Sodium
CAS No.	149690-05-1
Molecular Formula	C24H32NNaO5
Molecular Weight	437.51 g/mol
Synonyms	AHU-377 Sodium Salt; Sodium 4-{[(1S,3R)-1-([1,1'-Biphenyl]-4-ylmethyl)-4-ethoxy-3-methyl-4-oxobutyl]amino}-4-oxobutanoate; (2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-[(ethoxycarbonyl)amino]-2-methylpentanoic acid sodium salt; LCZ696 Sodium Salt; Sacubitril Na; Entresto Intermediate; Neprilysin Inhibitor Sodium Salt
EINECS	Contact for details

Quality Control

Our Sacubitril Sodium is manufactured under strict quality management systems, targeting compliance with ICH Q7 guidelines and current Good Manufacturing Practices (cGMP). Each batch is subjected to comprehensive analytical testing, including identification, purity assay, and impurity profiling via advanced techniques like HPLC. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to ensure full traceability and regulatory support for our clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.