Description

6-(Deoxyguanosin-N(2)-Yl)-3-Aminobenzo(A)Pyrene is a structurally defined adduct formed between a benzo[a]pyrene metabolite and deoxyguanosine. This compound is of significant value as a biomarker and reference standard for studying DNA damage and mutagenesis caused by polycyclic aromatic hydrocarbons (PAHs). It is primarily needed by research institutions, pharmaceutical R&D laboratories, and analytical testing facilities engaged in toxicology, carcinogenesis research, and environmental health science.

Application

• Biomarker Standard for DNA Adduct Analysis: Used as a high-purity reference material in LC-MS/MS, HPLC-fluorescence, and 32P-postlabeling assays to quantify exposure to benzo[a]pyrene.
• Mechanistic Toxicology Research: Critical for in vitro and in vivo studies investigating the formation, repair, and biological consequences of specific PAH-DNA adducts.
• Carcinogenesis and Mutagenesis Studies: Serves as a tool to understand the molecular mechanisms linking PAH exposure to genetic mutations and cancer initiation.
• Method Development and Validation: Employed by analytical laboratories to develop, calibrate, and validate sensitive detection methods for DNA damage products.
• Environmental and Occupational Health Monitoring: Supports studies assessing human exposure risks from combustion products, cigarette smoke, and industrial processes.
• Standards for Regulatory and Forensic Science: Provides a definitive standard for compliance testing and forensic analysis related to chemical exposure.

Basic Information

Product Name	6-(Deoxyguanosin-N(2)-Yl)-3-Aminobenzo(A)Pyrene
CAS No.	149635-27-8
Molecular Formula	C31H28N6O4
Molecular Weight	548.59 g/mol
Synonyms	N2-(3-Aminobenzo[a]pyren-6-yl)-2'-deoxyguanosine; 6-(Deoxyguanosin-N2-yl)-3-aminobenzo[a]pyrene; 3-Aminobenzo[a]pyrene-deoxyguanosine adduct; BP-6-N2dG; B[a]P-6-N2-dG Adduct; Benzo[a]pyrene-6-N2-deoxyguanosine; DNA Adduct of 3-Aminobenzo[a]pyrene
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research chemicals. Each batch is characterized using advanced analytical techniques to confirm identity and purity. Certificates of Analysis (COA) detailing batch-specific results from HPLC, NMR, and MS are available upon request. We adhere to a quality management system to ensure traceability and consistency for critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed under inert atmosphere or with desiccant after each use to maintain stability and purity.

Specification

Item	Specification
Appearance	Off-white to light tan solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area Percent)
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.