Description

Chondroitin Disaccharide Di-6S Sodium is a highly sulfated, defined disaccharide unit derived from the enzymatic or chemical depolymerization of chondroitin sulfate. This compound serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate for research and development in the life sciences. It is essential for scientists and manufacturers in the pharmaceutical, biotechnology, and nutraceutical industries who require high-purity, structurally-defined glycosaminoglycan (GAG) fragments for analytical calibration, bioactivity studies, and advanced therapeutic formulations.

Application

• Pharmaceutical Reference Standard: Used as a primary standard in HPLC, LC-MS, and CE methods for the quantification and qualification of chondroitin sulfate sources and finished products.
• Biomedical Research: Employed in studies investigating the structure-activity relationship of sulfated polysaccharides, particularly their interactions with growth factors, cytokines, and cell surface receptors.
• API Intermediate: Serves as a key building block in the synthesis of novel, homogeneous heparin/heparan sulfate mimetics and other glycosaminoglycan-based therapeutics.
• Diagnostic Reagent Development: Utilized in the development of enzymatic assay kits and biosensors for detecting specific sulfation patterns in biological samples.
• Cell Culture & Regenerative Medicine: Applied in substrate coating or media supplementation to study its effects on stem cell differentiation, neurite outgrowth, and tissue engineering.
• Quality Control (QC) Testing: Essential for in-house QC laboratories of dietary supplement and pharmaceutical manufacturers to verify the disaccharide composition of chondroitin sulfate raw materials.

Basic Information

Product Name	Chondroitin Disaccharide Di-6S Sodium
CAS No.	149458-08-2
Molecular Formula	C14H19NNa3O19S2
Molecular Weight	694.45 g/mol
Synonyms	δDi-6S; Chondroitin sulfate disaccharide δDi-6S sodium salt; Sodium Chondroitin Disulfate Disaccharide; 2-Acetamido-2-deoxy-3-O-(β-D-gluco-4-enepyranosyluronic acid)-4-O-sulfo-D-galactose sodium salt; 4,5-Unsaturated Chondroitin Disaccharide Di-6S Sodium; ADi-6S; Chondroitin Disaccharide Di-Sodium Salt (6S/6S); CS Disaccharide δDi-6S
EINECS	Contact for details

Quality Control

Our Chondroitin Disaccharide Di-6S Sodium is manufactured under a strict quality management system. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation and NMR for structural verification, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	15.0% - 25.0%
Heavy Metals	≤ 20 ppm
Bacterial Endotoxins	< 10 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.