Description

Cidofovir CAS NO 149394-66-1 is a potent antiviral nucleotide analog with significant therapeutic applications. Its primary value lies in its targeted mechanism of action against DNA viruses, offering a critical treatment option where other therapies fail. This compound is essential for pharmaceutical manufacturers and research institutions focused on developing and producing antiviral medications, particularly for treating cytomegalovirus (CMV) retinitis in immunocompromised patients.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active pharmaceutical ingredient in antiviral injectable formulations.
• CMV Retinitis Treatment: Manufacture of medications for the treatment of cytomegalovirus (CMV) retinitis in AIDS patients.
• Antiviral Research: A key reference standard and investigational compound in virology and antiviral drug discovery programs.
• Treatment of Acyclovir-Resistant HSV: Used in compounded or formulated treatments for herpes simplex virus (HSV) infections resistant to first-line therapies.
• Vaccinia & Smallpox Research: Investigated for use in treating complications from vaccinia virus and as a potential therapeutic for orthopoxviruses.
• Adjunct Therapy in Transplant Medicine: Potential prophylactic or treatment use for viral infections in organ transplant recipients.
• Ophthalmic Solution Development: Research and development of topical or intravitreal formulations for ocular viral infections.
• Chemical Intermediate: Serves as a sophisticated intermediate for the synthesis of novel nucleotide-based prodrugs and analogs.

Basic Information

Product Name	Cidofovir
CAS No.	149394-66-1
Molecular Formula	C8H14N3O6P
Molecular Weight	279.19 g/mol
Synonyms	(S)-HPMPC; GS-504; Vistide (Brand Name); 1-[(S)-3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine; (S)-1-[3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine; Cidofovir Anhydrous; CDV; HPMPC
EINECS	Contact for details

Quality Control

Our Cidofovir is manufactured under strict quality systems to ensure it meets the rigorous standards required for pharmaceutical applications. Each batch is subjected to comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via advanced techniques like HPLC and NMR. A Certificate of Analysis (COA) detailing all specifications and results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term stability, storage under an inert atmosphere such as nitrogen or argon is recommended.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Microbial Limits	Meets USP <61> requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.