Description

(R)-(+)-1-(2-Diphenylphosphino-1-Naphthyl)Isoquinoline is a high-value, chiral monodentate phosphine ligand essential for asymmetric catalysis. Its unique steric and electronic properties make it a critical component for achieving high enantioselectivity in transition-metal-catalyzed reactions. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for synthesizing chiral intermediates and active ingredients.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for the synthesis of enantiomerically pure pharmaceutical intermediates.
• Catalyst component for asymmetric C-C bond-forming reactions, such as cross-coupling and allylic substitution.
• Key reagent in the development of novel catalytic systems for academic and industrial research in asymmetric synthesis.
• Used in the preparation of chiral compounds for agrochemicals and specialty materials.
• Critical for process chemistry optimization to improve yield and enantiomeric excess (ee) in scale-up manufacturing.

Basic Information

Product Name	(R)-(+)-1-(2-Diphenylphosphino-1-Naphthyl)Isoquinoline
CAS No.	149341-34-4
Molecular Formula	C₃₃H₂₄NP
Molecular Weight	465.52 g/mol
Synonyms	(R)-(+)-1-(2-Diphenylphosphino-1-naphthyl)isoquinoline; (R)-1-[(R)-2-(Diphenylphosphino)-1-naphthalenyl]isoquinoline; (R)-QUINAP; (R)-2-Diphenylphosphino-1-(1-isoquinolyl)naphthalene; (R)-1-[2-(Diphenylphosphino)-1-naphthyl]isoquinoline; (R)-1-(2-Diphenylphosphino-1-naphthyl)isoquinoline; (R)-1-(2-DPPN)Isoquinoline; (R)-QUINAP Ligand
EINECS	Contact for details

Quality Control

Our (R)-(+)-1-(2-Diphenylphosphino-1-Naphthyl)Isoquinoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for advanced catalytic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee reproducible performance and lot-to-lot consistency for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label or COA. This compound is easily oxidized and light-sensitive; prolonged exposure to air or light should be avoided to maintain stability and catalytic activity.

Specification

Item	Specification
Appearance	Yellow to orange powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.