Description

(R)-(+)-1-(2-Diphenylphosphino-1-Naphthyl)Isoquinoline is a high-value, chiral monodentate phosphine ligand with a rigid, bulky structure. This compound matters because it is essential for creating highly efficient and selective asymmetric catalysts, particularly in transition metal-catalyzed cross-coupling and hydrogenation reactions. Pharmaceutical R&D laboratories, fine chemical manufacturers, and academic research institutions need it to develop novel chiral intermediates and active pharmaceutical ingredients (APIs) with high enantiomeric purity.

Application

• As a key chiral ligand in asymmetric hydrogenation reactions for the synthesis of enantiomerically pure amines, alcohols, and acids.
• Catalyst component in asymmetric cross-coupling reactions (e.g., Suzuki-Miyaura, Buchwald-Hartwig) to form C-C and C-N bonds with high stereoselectivity.
• Critical reagent in the research and development of novel pharmaceutical compounds requiring specific chiral configurations.
• Used in the synthesis of advanced materials and specialty chemicals where precise stereochemical control is paramount.
• Tool compound in academic and industrial research for studying and developing new asymmetric catalytic methodologies.

Basic Information

Product Name	(R)-(+)-1-(2-Diphenylphosphino-1-Naphthyl)Isoquinoline
CAS No.	149341-33-3
Molecular Formula	C₃₃H₂₄NP
Molecular Weight	465.52 g/mol
Synonyms	(R)-(+)-1-[2-(Diphenylphosphino)-1-naphthyl]isoquinoline; (R)-1-[(2-Diphenylphosphino)-1-naphthyl]isoquinoline; (R)-QUINAP; (R)-2-Diphenylphosphino-1-(1-isoquinolyl)naphthalene; (R)-(+)-1-(2-Diphenylphosphino-1-naphthyl)isoquinoline; (R)-1-(2-(Diphenylphosphanyl)naphthalen-1-yl)isoquinoline; (R)-1-[2-(Diphenylphosphino)naphthalen-1-yl]isoquinoline; (R)-QUINAP Ligand
EINECS	Contact for details

Quality Control

Every batch of our (R)-(+)-1-(2-Diphenylphosphino-1-Naphthyl)Isoquinoline is produced and tested under strict quality management systems. We ensure high chiral purity and chemical integrity through advanced analytical techniques including HPLC, NMR, and chiral analysis. Certificates of Analysis (COA) with detailed specifications for identity, purity, and enantiomeric excess are provided to guarantee compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its sensitivity to oxidation, the container should be purged with inert gas before resealing after each use.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.