Description

Tricolorin A CAS NO 149155-65-7 is a specialized natural product compound belonging to the class of resin glycosides, isolated from plants of the *Ipomoea* genus. This compound matters for its significant biological activity, particularly as a potent and specific inhibitor of mammalian DNA polymerase β, making it a valuable tool in biochemical research and drug discovery. It is needed by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on oncology, enzymology, and the development of novel therapeutic agents targeting DNA replication and repair pathways.

Application

• Biochemical Research: As a selective inhibitor of DNA polymerase β for studying DNA repair mechanisms, base excision repair (BER), and cellular response to DNA damage.
• Pharmaceutical R&D: A key reference standard and lead compound in the discovery and development of novel chemotherapeutic agents and radiosensitizers.
• Enzymology Studies: Used to investigate the structure-activity relationships (SAR) of polymerase inhibitors and to elucidate the enzymatic functions of polymerases.
• Cell Biology: Employed in *in vitro* assays to probe cell cycle regulation, apoptosis, and the role of specific polymerases in maintaining genomic stability.
• Academic Research: A critical reagent for universities and research institutes conducting fundamental studies in molecular biology, genetics, and cancer biology.
• Standards and Controls: Serves as a high-purity analytical standard for quality control in related natural product extraction and for metabolite identification.

Basic Information

Product Name	Tricolorin A
CAS No.	149155-65-7
Molecular Formula	C56H86O24
Molecular Weight	1143.27 g/mol
Synonyms	Ipomoeassin F; (2S,3R,4S,5S,6R)-2-[[(2R,3R,4S,5R,6R)-6-[[(3S,4aR,6aR,7S,10aS,10bS,12aS)-3-[(2S,3R,4S,5S)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-7-hydroxy-6a,10b-dimethyl-1,2,3,4,4a,5,6,6a,7,10,10a,10b,11,12,12a-tetradecahydrobenzo[a]fluoren-9-yl]oxy]-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol; Resin Glycoside Tricolorin A; DNA Polymerase beta Inhibitor Tricolorin A
EINECS	Contact for details

Quality Control

Our Tricolorin A is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and other relevant identity tests. A detailed Certificate of Analysis (COA) documenting all specifications and test results is provided with every shipment to support your compliance and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Allow the product to equilibrate to room temperature in a dry environment before opening to prevent condensation. The container should be kept in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.