Description

L-Ascorbic Acid-6-13C CAS NO 149153-08-2 is a stable isotope-labeled analog of Vitamin C, where the carbon atom at the 6-position is enriched with the 13C isotope. This compound is essential for advanced research and analytical applications requiring precise metabolic tracing and quantification. It is primarily utilized by pharmaceutical R&D laboratories, clinical research organizations, and manufacturers of high-end diagnostic kits for applications in mass spectrometry, NMR spectroscopy, and pharmacokinetic studies.

Application

• Isotope Dilution Mass Spectrometry (IDMS): Serves as an internal standard for the accurate quantification of endogenous ascorbic acid in complex biological matrices like plasma, serum, and tissue homogenates.
• Metabolic Pathway Tracing: Used in in vitro and in vivo studies to elucidate the absorption, distribution, metabolism, and excretion (ADME) pathways of Vitamin C.
• Clinical Diagnostics: A critical component in the development and calibration of LC-MS/MS assays for measuring Vitamin C status in nutritional and disease-state monitoring.
• Pharmaceutical R&D: Employed in drug metabolism and pharmacokinetics (DMPK) studies for new formulations containing or affecting Vitamin C levels.
• Nutritional Science Research: Enables precise studies on Vitamin C bioavailability, turnover, and its role as an antioxidant in cellular systems.
• Quality Control Reference Standard: Acts as a certified reference material for ensuring the accuracy and precision of analytical methods in quality control laboratories.

Basic Information

Item	Detail
Product Name	L-Ascorbic Acid-6-13C
CAS No.	149153-08-2
Molecular Formula	C512C13H8O6
Molecular Weight	177.12 g/mol (for 13C1 labeled form)
Synonyms	Vitamin C-6-13C; (5R)-5-[(1S)-1,2-Dihydroxyethyl]-3,4-dihydroxyfuran-2(5H)-one-6-13C; 13C1-L-Ascorbic Acid; Ascorbic Acid-6-13C; 3-Oxo-L-gulofuranolactone-6-13C; L-Threo-hex-2-enono-1,4-lactone-6-13C; Isotopically Labeled Vitamin C
EINECS	Contact for details

Quality Control

Every batch of our L-Ascorbic Acid-6-13C is manufactured and analyzed under strict quality systems. We provide comprehensive analytical data to ensure it meets the high standards required for research and diagnostic applications. Certificates of Analysis (COA) are supplied with each shipment, detailing parameters such as isotopic purity, chemical purity, and absence of specific impurities. Our quality commitment aligns with the needs of cGMP and ISO 17025-accredited environments.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under inert atmosphere. This product is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0% (Chemical Purity)
Isotopic Purity (MS)	≥ 99 atom % 13C
Isotopic Enrichment	≥ 99% at C-6 position
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Optical Rotation	+20.5° to +21.5°

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.