Description

Ent-Ivabradine Hydrochloride CAS NO 148849-68-7 is the enantiomerically pure form of the selective sinus node If channel inhibitor, ivabradine. This high-purity chiral intermediate is critical for pharmaceutical research and development, particularly in the study of cardiac electrophysiology and the development of enantiomer-specific heart rate-lowering agents. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on cardiovascular drug discovery and process chemistry.

Application

• Pharmaceutical Reference Standard: Serves as a critical chiral reference material for analytical method development, validation, and quality control in the production of ivabradine-based therapeutics.
• Cardiovascular Research: Used as a key pharmacological tool to study the specific effects of the (ent)-enantiomer on the If current in sinoatrial node cells and heart rate regulation.
• Process Chemistry & Impurity Profiling: Essential for identifying and quantifying the enantiomeric impurity in bulk ivabradine hydrochloride, supporting the development of robust, stereoselective synthetic routes.
• Active Pharmaceutical Ingredient (API) Development: Employed in the research and early-stage development of novel enantiopure cardiovascular drugs that target the If channel.
• Metabolic and Pharmacokinetic Studies: Utilized to investigate the distinct absorption, distribution, metabolism, and excretion (ADME) profile of the individual ivabradine enantiomer.

Basic Information

Product Name	Ent-Ivabradine Hydrochloride
CAS No.	148849-68-7
Molecular Formula	C27H37N2O5•HCl
Molecular Weight	505.06 g/mol
Synonyms	(ent)-Ivabradine Hydrochloride; (3R)-3-[[(7S)-3,4-Dimethoxy-7,8,9,10-tetrahydro-6,7,10,11-tetrahydro-6H-cyclohepta[b]quinolin-9-yl]methyl]-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol Hydrochloride; UNII-9V8V49E0KQ; (ent)-S 16257 Hydrochloride; Ivabradine (ent)-Enantiomer Hydrochloride; (3R,7S)-Ivabradine Hydrochloride
EINECS	Contact for details

Quality Control

Our Ent-Ivabradine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity, standard pharmacopeial identification tests, and stringent control of related substances and residual solvents. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specifications for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.