Description

Seco Rapamycin Sodium Salt is a chemically modified derivative of the potent immunosuppressant and mTOR inhibitor, rapamycin. This sodium salt form is designed to enhance solubility and stability, making it a critical intermediate for advanced pharmaceutical research and development. It is primarily utilized by researchers and manufacturers in the fields of immunology, oncology, and anti-aging therapeutics to develop novel drug candidates and conduct mechanistic studies.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel rapamycin analogs and prodrugs for enhanced therapeutic profiles.
• Biochemical Research: Used as a research tool to study mTOR (mammalian target of rapamycin) signaling pathways and their role in cell growth, proliferation, and autophagy.
• Immunosuppressant Development: Investigated for the development of next-generation immunosuppressive agents with potential applications in organ transplantation and autoimmune diseases.
• Oncology Research: Employed in cancer research to explore the anti-proliferative effects of mTOR inhibition on various tumor cell lines.
• Anti-Aging & Longevity Studies: Utilized in preclinical studies investigating the role of mTOR modulation in aging processes and age-related diseases.
• Formulation Development: Acts as a model compound for developing stable injectable or oral formulations due to its improved solubility characteristics.

Basic Information

Product Name	Seco Rapamycin Sodium Salt
CAS No.	148554-65-8
Molecular Formula	C51H78NO14•Na
Molecular Weight	968.15 g/mol (approx.)
Synonyms	Seco-Rapamycin Sodium Salt; 42-O-(2-Hydroxyethyl)rapamycin Sodium Salt; 42-O-(2-Hydroxyethyl) Sirolimus Sodium Salt; Rapamycin Seco-Derivative Sodium Salt; mTOR Inhibitor Derivative Sodium Salt; 29,42-Seco-rapamycin Sodium Salt; ABT-578 derivative sodium salt
EINECS	Contact for details

Quality Control

Our Seco Rapamycin Sodium Salt is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. A Certificate of Analysis (COA) detailing all specifications is provided to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines
Assay (on anhydrous basis)	97.0% - 103.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.