Description

(4S)-tert-Butyl-2-[2-(Diphenylphosphino)Phenyl]-4,5-Dihydrooxazole is a high-value chiral P,N-ligand, a critical component in asymmetric catalysis. Its importance lies in enabling highly enantioselective transformations, which are essential for the efficient synthesis of single-enantiomer pharmaceuticals and fine chemicals. This product is primarily needed by research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries for developing and scaling up catalytic processes.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones, crucial for producing chiral intermediates in active pharmaceutical ingredients (APIs).
• Asymmetric C-C Bond Formation: Used in cross-coupling reactions, allylic alkylations, and other C-C bond-forming processes to construct complex chiral molecules with high stereocontrol.
• Pharmaceutical Intermediate Synthesis: Facilitates the production of enantiomerically pure building blocks for drug candidates targeting central nervous system (CNS) disorders, cardiovascular diseases, and oncology.
• Agrochemical Synthesis: Employed in the development of chiral pesticides and herbicides to enhance efficacy and reduce environmental impact.
• Academic & Industrial Research: A vital tool for methodology development in academic laboratories and for process optimization in industrial R&D settings.
• Catalyst Screening Libraries: Serves as a component in high-throughput screening kits for discovering new asymmetric catalytic reactions.

Basic Information

Product Name	(4S)-tert-Butyl-2-[2-(Diphenylphosphino)Phenyl]-4,5-Dihydrooxazole
CAS No.	148461-16-9
Molecular Formula	C25H26NOP
Molecular Weight	387.45 g/mol
Synonyms	(S)-tert-Butyl-2-[2-(Diphenylphosphino)Phenyl]-4,5-Dihydrooxazole; (S)-t-Bu-PHOX; (S)-2-[2-(Diphenylphosphino)phenyl]-4-(1,1-dimethylethyl)-4,5-dihydrooxazole; (4S)-4-(tert-Butyl)-2-[2-(diphenylphosphanyl)phenyl]-4,5-dihydro-1,3-oxazole; (S)-4-tert-Butyl-2-(2-diphenylphosphinophenyl)-2-oxazoline; PHOX Ligand; Josiphos-type ligand derivative
EINECS	Contact for details

Quality Control

Our (4S)-tert-Butyl-2-[2-(Diphenylphosphino)Phenyl]-4,5-Dihydrooxazole is manufactured under strict quality control protocols to ensure high chemical and enantiomeric purity, which is critical for reproducible catalytic performance. Each batch is characterized by NMR, HPLC, and specific optical rotation analysis. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (ee)	≥ 99.0%
Specific Optical Rotation [α]D20	Contact for details
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.