Description

S(+)-2-[2-(Diphenylphosphino)Phenyl]-4-Phenyl-2-Oxazoline is a high-value, chiral P,N-ligand widely utilized in asymmetric catalysis. Its significance lies in its ability to induce high enantioselectivity in transition metal-catalyzed reactions, which is critical for producing optically pure intermediates. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control in synthetic processes.

Application

• As a chiral ligand for asymmetric hydrogenation of olefins, ketones, and imines.
• As a key component in rhodium-catalyzed asymmetric conjugate additions.
• For palladium-catalyzed asymmetric allylic alkylation (AAA) reactions.
• In the synthesis of enantiomerically pure pharmaceutical intermediates and active ingredients.
• For the development of novel catalytic systems in academic and industrial R&D.
• In the production of specialty agrochemicals requiring specific stereochemistry.
• As a reference standard for analytical method development and quality control.

Basic Information

Product Name	S(+)-2-[2-(Diphenylphosphino)Phenyl]-4-Phenyl-2-Oxazoline
CAS No.	148461-15-8
Molecular Formula	C27H22NOP
Molecular Weight	407.45 g/mol
Synonyms	(S)-2-[2-(Diphenylphosphino)phenyl]-4-phenyl-4,5-dihydrooxazole; (S)-2-[2-(Diphenylphosphino)phenyl]-4-phenyl-2-oxazoline; (S)-PHOX; (S)-2-(2-Diphenylphosphinophenyl)-4-phenyl-2-oxazoline; S-PHOX Ligand; (S)-4-Phenyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydrooxazole; (S)-2-(2-Diphenylphosphanylphenyl)-4-phenyl-4,5-dihydrooxazole
EINECS	Contact for details

Quality Control

Our S(+)-2-[2-(Diphenylphosphino)Phenyl]-4-Phenyl-2-Oxazoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical and chiral purity, meeting the stringent requirements for catalysis research and process development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific rotation is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Due to its sensitivity to oxidation, the container should only be opened in an inert environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Specific Rotation	Contact for details
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.