Description

(4S)-(-)-4,5-Dihydro-2-[2'-(Diphenylphosphino)Phenyl]-4-Isopropyloxazole is a high-value chiral phosphine-oxazoline (PHOX) ligand, a cornerstone in modern asymmetric catalysis. Its precise stereochemistry and electronic properties make it indispensable for creating enantiomerically pure compounds, which are critical in pharmaceutical and fine chemical synthesis. This ligand is primarily sought by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for applications requiring high enantioselectivity and yield.

Application

• Asymmetric hydrogenation reactions for the synthesis of chiral amino acids and pharmaceutical intermediates.
• Asymmetric allylic substitution reactions to construct complex, stereodefined carbon frameworks.
• Asymmetric hydroboration and hydrosilylation processes in fine chemical manufacturing.
• Key chiral ligand in transition metal catalysis for the production of enantiopure agrochemicals.
• Catalyst component in academic and industrial research for developing new asymmetric transformations.
• Use in the synthesis of active pharmaceutical ingredients (APIs) requiring a single enantiomer.

Basic Information

Product Name	(4S)-(-)-4,5-Dihydro-2-[2'-(Diphenylphosphino)Phenyl]-4-Isopropyloxazole
CAS No.	148461-14-7
Molecular Formula	C24H24NOP
Molecular Weight	373.43 g/mol
Synonyms	(S)-(-)-2-(2-(Diphenylphosphino)phenyl)-4-isopropyl-4,5-dihydrooxazole; (S)-4-Isopropyl-2-(2-(diphenylphosphino)phenyl)-4,5-dihydrooxazole; (S)-PHOX Ligand; (S)-2-[2-(Diphenylphosphino)phenyl]-4-isopropyl-4,5-dihydrooxazole; L-748,328 (as a catalyst precursor complex); (S)-t-Bu-PHOX; Chiral PHOX ligand; (4S)-4-Isopropyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-1,3-oxazole
EINECS	Contact for details

Quality Control

Every batch of our (4S)-(-)-PHOX ligand is manufactured and tested under strict quality management systems to ensure exceptional purity and chiral integrity, critical for reproducible catalytic performance. We provide comprehensive Certificates of Analysis (COA) detailing purity, enantiomeric excess, and key spectroscopic data. Our quality protocols are designed to meet the stringent requirements of cGMP and ISO standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to prevent oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.