Description

(4S)-2-[2-(Diphenylphosphino)Phenyl]-4,5-Dihydro-4-(Phenylmethyl)-Oxazole CAS NO 148461-13-6 is a high-value, chiral phosphine-oxazoline ligand, a critical component in asymmetric catalysis. Its primary value lies in enabling highly enantioselective transformations, which are essential for the efficient and cost-effective synthesis of single-enantiomer pharmaceuticals and fine chemicals. This product is specifically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control in their synthetic routes.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for pharmaceutical intermediates.
• Catalyst component for enantioselective C-C bond-forming reactions, such as allylic alkylation.
• Use in the synthesis of active pharmaceutical ingredients (APIs) requiring high enantiomeric purity.
• Key reagent in academic and industrial research for developing new asymmetric catalytic processes.
• Potential application in the synthesis of chiral agrochemicals and flavors/fragrances.
• As a precursor or modifier for immobilized catalysts used in continuous flow chemistry.

Basic Information

Product Name	(4S)-2-[2-(Diphenylphosphino)Phenyl]-4,5-Dihydro-4-(Phenylmethyl)-Oxazole
CAS No.	148461-13-6
Molecular Formula	C28H24NOP
Molecular Weight	421.47 g/mol
Synonyms	(S)-2-[2-(Diphenylphosphino)phenyl]-4-benzyl-4,5-dihydrooxazole; (S)-4-Benzyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydrooxazole; (S)-PHOX Ligand; (S)-2-(2-Diphenylphosphinophenyl)-4-benzyl-2-oxazoline; (S)-2-(2-Diphenylphosphinophenyl)-4-benzyl-4,5-dihydrooxazole; (S)-2-(Diphenylphosphino)phenyl-4-benzyl-oxazoline; (S)-Benzyl-PHOX; Chiral PHOX Ligand
EINECS	Contact for details

Quality Control

Our (4S)-2-[2-(Diphenylphosphino)Phenyl]-4,5-Dihydro-4-(Phenylmethyl)-Oxazole is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, NMR for structural confirmation, and ICP-MS for trace metal analysis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and chiral purity is provided with every shipment to ensure it meets the exacting standards required for advanced catalytic applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label or COA. This compound is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Allow the sealed container to reach ambient temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.