Description

(4S)-(-)-4,5-Dihydro-2-[2'-(Diphenylphosphino)Phenyl]-4-Isopropyloxazole is a high-value chiral phosphine-oxazoline (PHOX) ligand, a cornerstone in asymmetric catalysis. Its importance lies in enabling highly enantioselective transformations, critical for producing single-isomer pharmaceuticals and fine chemicals with superior purity and efficacy. This product is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-performance ligands for C-C bond formation and hydrogenation reactions.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of olefins, ketones, and imines in pharmaceutical intermediate synthesis.
• Asymmetric C-C Bond Formation: Catalyzes critical reactions like Heck, Suzuki, and allylic alkylation with high stereoselectivity.
• Pharmaceutical Intermediate Manufacturing: Used in the production of chiral active pharmaceutical ingredients (APIs) for various therapeutic areas.
• Agrochemical Synthesis: Enables the creation of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: A vital tool for developing new catalytic methodologies and exploring novel synthetic routes.
• Fine Chemical Production: Applied in the synthesis of complex, high-value fragrance and flavor compounds.

Basic Information

Item	Details
Product Name	(4S)-(-)-4,5-Dihydro-2-[2'-(Diphenylphosphino)Phenyl]-4-Isopropyloxazole
CAS No.	148461-12-5
Molecular Formula	C24H24NOP
Molecular Weight	373.43 g/mol
Synonyms	(S)-(-)-2-[2-(Diphenylphosphino)phenyl]-4-isopropyl-4,5-dihydrooxazole; (S)-4-Isopropyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydrooxazole; (S)-PHOX Ligand; (S)-2-[2-(Diphenylphosphino)phenyl]-4-isopropyl-2-oxazoline; (S)-t-Bu-PHOX; L1; (S)-4,5-Dihydro-2-[2-(diphenylphosphino)phenyl]-4-(1-methylethyl)oxazole; (4S)-4,5-Dihydro-2-[2-(diphenylphosphino)phenyl]-4-(propan-2-yl)-1,3-oxazole
EINECS	Contact for details

Quality Control

Our (4S)-(-)-4,5-Dihydro-2-[2'-(Diphenylphosphino)Phenyl]-4-Isopropyloxazole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and NMR for structural confirmation, to ensure high purity and consistent performance. Certificates of Analysis (COA) with detailed specifications are provided for traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to prevent oxidation and maintain stability. Keep the container in a cool, dry, well-ventilated place separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.