Description

4-(Difluorochloromethoxy)Benzoic Acid is a specialized fluorinated benzoic acid derivative that serves as a critical building block in advanced organic synthesis. This compound matters for its unique molecular structure, which incorporates both fluorine and chlorine atoms on the methoxy linker, enabling precise modulation of electronic and steric properties in target molecules. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting enzyme inhibition.
• Agrochemical Synthesis: Used in the preparation of advanced herbicides and pesticides, where the difluorochloromethoxy group can enhance bioavailability and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for display technologies.
• Polymer Chemistry: Acts as a monomer or modifier for introducing fluorine-containing functionalities into polymers to alter surface properties and chemical resistance.
• Organic Synthesis Building Block: Employed in cross-coupling reactions and as a precursor for more complex benzoic acid derivatives in academic and industrial research.

Basic Information

Product Name	4-(Difluorochloromethoxy)Benzoic Acid
CAS No.	147992-34-5
Molecular Formula	C8H5ClF2O3
Molecular Weight	222.57 g/mol
Synonyms	Benzoic acid, 4-[(chlorodifluoromethoxy)]-; 4-[(Chlorodifluoromethoxy)]benzoic acid; p-(Difluorochloromethoxy)benzoic acid; 4-(Chlorodifluoromethoxy)benzoic acid; 147992-34-5; Difluorochloromethoxybenzoic Acid; 4-(Difluorochloromethoxy)-benzoic acid
EINECS	Contact for details

Quality Control

Our 4-(Difluorochloromethoxy)Benzoic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. Due to its nature as a strong acid/organic solvent, handle with appropriate personal protective equipment in a fume hood.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.