Description

Siramesine is a selective σ-2 receptor ligand with significant research interest in the field of neuroscience and oncology. This compound matters as a valuable pharmacological tool for investigating cellular mechanisms related to apoptosis, cholesterol homeostasis, and neurological disorders. It is primarily needed by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in preclinical studies for cancer therapeutics and central nervous system (CNS) drug discovery.

Application

• Pharmacological Research: Used as a reference standard and active compound in studies targeting σ-2 receptors.
• Oncology Research: Investigated for its pro-apoptotic effects and potential in cancer cell death mechanisms.
• Neuropharmacology: Employed in research models for neurodegenerative diseases, depression, and psychosis.
• Biochemical Assay Development: Serves as a key ligand in developing binding assays and screening tests for σ-2 receptor activity.
• Academic & Institutional R&D: Utilized in university and institutional labs for fundamental research on receptor biology and signal transduction.
• Drug Discovery Pipeline: Acts as a lead compound or chemical probe in early-stage pharmaceutical development for novel therapeutics.

Basic Information

Product Name	Siramesine
CAS No.	147817-50-3
Molecular Formula	C₂₃H₂₈N₂O₂
Molecular Weight	364.48 g/mol
Synonyms	Lu 28-179; Lu28-179; (3R,4S)-3-(3,4-Dichlorophenyl)-1-methyl-4-[(4-phenyl-1-piperazinyl)methyl]-4-piperidinol; 4-Piperidinol, 3-(3,4-dichlorophenyl)-1-methyl-4-[(4-phenyl-1-piperazinyl)methyl]-, (3R,4S)-; σ-2 Receptor Ligand Lu 28-179
EINECS	Contact for details

Quality Control

Our Siramesine is produced under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for research applications. Each batch is accompanied by comprehensive analytical documentation. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.