Description

L-Glutamic Acid-[3,4-3H] is a high-specific-activity tritium-labeled derivative of the essential amino acid L-glutamic acid, identified by CAS NO 147732-35-2. This compound is critical for advanced biochemical research, enabling precise metabolic pathway tracing, receptor binding studies, and pharmacokinetic analysis. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on neuroscience, metabolism, and drug discovery.

Application

• Biochemical Tracer Studies: Used as a radiolabeled tracer to investigate glutamic acid metabolism, transport mechanisms, and turnover rates in biological systems.
• Neuropharmacology Research: Essential for autoradiography and binding assays to study glutamate receptors (e.g., NMDA, AMPA, kainate receptors) in the central nervous system.
• Drug Discovery & Development: Employed in high-throughput screening (HTS) and in vitro assays to evaluate the efficacy and mechanism of action of novel neuroactive compounds.
• Metabolic Pathway Analysis: Facilitates the detailed mapping of metabolic fluxes in cancer cells, microorganisms, and plant systems where glutamic acid is a key intermediate.
• Protein & Peptide Labeling: Serves as a building block for incorporating tritium labels into peptides and proteins for stability and interaction studies.
• Environmental & Agricultural Research: Applied in studies of nitrogen assimilation and amino acid metabolism in plants and soil microbes.

Basic Information

Product Name	L-Glutamic Acid-[3,4-3H]
CAS No.	147732-35-2
Molecular Formula	C5H73H2NO4 *
Molecular Weight	~150.1 g/mol (for unlabeled form; exact MW varies with specific activity)
Synonyms	(2S)-2-Aminopentanedioic-3,4-3H acid; L-Glutamic-3,4-3H Acid; Tritiated L-Glutamic Acid; [3,4-3H]-L-Glutamate; H-Glu-OH-3,4-3H; (S)-2-Amino-1,5-3H-pentanedioic acid; Glutamic Acid, L- (tritiated); 3,4-Tritio-L-glutamic acid
EINECS	Contact for details

* Formula indicates tritium (3H) labeling at the 3 and 4 positions of the carbon chain.

Quality Control

Every batch of L-Glutamic Acid-[3,4-3H] is manufactured and controlled under strict quality systems. Product integrity is verified through comprehensive analytical testing, including determination of radiochemical purity (by HPLC) and specific activity (by liquid scintillation counting). All materials are supplied with a detailed Certificate of Analysis (COA) that documents batch-specific data, ensuring traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store frozen (-20°C or below) in the original solvent as supplied. For long-term storage, keep at -70°C to -80°C. The product is strictly light-sensitive (protect from all light exposure). Always handle in accordance with laboratory safety protocols for radioactive materials.

Specification

Item	Specification
Appearance	Clear solution (colorless to slightly yellow)
Identification (HPLC, MS)	Conforms to reference standard
Specific Activity	20-60 Ci/mmol (Contact for exact value)
Radiochemical Purity (HPLC)	≥ 95%
Chemical Purity (HPLC)	≥ 98%
Solvent	Ethanol:Water mixture (specified on COA)
Concentration	1 mCi/mL (Contact for other concentrations)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.