Description

(+/-)-Ortho-Cotinine CAS NO 147732-31-8 is a high-purity chemical reference standard and a key intermediate in advanced pharmaceutical research and development. This compound is of significant interest for its role in the study of nicotine metabolism and related biochemical pathways. It is primarily utilized by research institutions, analytical laboratories, and pharmaceutical companies engaged in the development of smoking cessation aids, diagnostic assays, and metabolic studies. Our product is supplied with full traceability and rigorous quality control to ensure reliable and reproducible results for your critical applications.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the calibration of analytical instruments and validation of methods in pharmacokinetic studies.
• Metabolite Research: Serves as a critical intermediate or metabolite analog in research focused on nicotine catabolism and biomarker discovery.
• Diagnostic Development: Employed in the development and manufacturing of immunoassays and diagnostic kits for detecting tobacco use and exposure.
• Biochemical Synthesis: Acts as a building block or precursor in the organic synthesis of more complex molecules for pharmacological evaluation.
• Academic & Contract Research: Essential for universities and CROs (Contract Research Organizations) conducting studies in neurochemistry, addiction science, and toxicology.
• Quality Control: Used as an impurity standard or system suitability check in the QC laboratories of pharmaceutical manufacturers.

Basic Information

Product Name	(+/-)-Ortho-Cotinine
CAS No.	147732-31-8
Molecular Formula	C10H12N2O
Molecular Weight	176.22 g/mol
Synonyms	2'-Cotinine; ortho-Cotinine; 5-(3-Pyridinyl)-1H-pyrrol-2(5H)-one; 1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone (racemic); DL-ortho-Cotinine; (±)-2'-Cotinine; Cotinine Impurity; Nicotine Metabolite Analog
EINECS	Contact for details

Quality Control

Every batch of (+/-)-Ortho-Cotinine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to support its use as a research standard, including identity confirmation by spectroscopic methods and purity determination by chromatographic techniques. A Certificate of Analysis (COA) detailing batch-specific results is supplied with each shipment, ensuring full transparency and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.