Description

Abt-418 Hydrochloride is a high-purity organic compound, specifically a hydrochloride salt form of a selective cholinergic agent. This compound is of significant interest in advanced pharmaceutical research and development due to its role as a key intermediate or active pharmaceutical ingredient (API) in neurological studies. It is primarily utilized by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in the synthesis of novel therapeutics targeting cognitive function.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of potential drug candidates for central nervous system (CNS) disorders.
• Neurological Research: Used as a reference standard or active compound in preclinical studies investigating cholinergic pathways, cognitive enhancement, and memory function.
• Active Pharmaceutical Ingredient (API) Development: Employed in the formulation development and stability testing of new pharmaceutical products.
• Biochemical Assays: Functions as a ligand or modulator in in vitro assays to study receptor binding affinity and pharmacological activity.
• Contract Manufacturing: Supplied to CDMOs for scale-up synthesis under current Good Manufacturing Practice (cGMP) conditions for clinical trial material production.

Basic Information

Product Name	Abt-418 Hydrochloride
CAS No.	147388-83-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	ABT-418 HCl; (S)-3-Methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole hydrochloride; Ispronicline hydrochloride; TC-1734; AZD-0328; (S)-3-Methyl-5-(2-pyrrolidinyl)isoxazole hydrochloride; 5-[(2S)-2-Pyrrolidinyl]-3-methylisoxazole hydrochloride
EINECS	Contact for details

Quality Control

Our Abt-418 Hydrochloride is manufactured and tested under a rigorous quality management system. Each batch is subjected to comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets stringent specifications suitable for research and development use. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. We can support development programs requiring material produced under cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to prevent degradation. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.