Description

Ipp, [1-14C] is a carbon-14 labeled isotopologue of the isopentenyl pyrophosphate (IPP) molecule, a fundamental building block in isoprenoid biosynthesis. This radiolabeled compound is essential for tracing and quantifying metabolic flux in the mevalonate and non-mevalonate pathways. It is a critical research tool for scientists in pharmaceutical development, metabolic engineering, and plant biochemistry who require precise tracking of terpenoid and steroid production.

Application

• Metabolic Pathway Tracing: Used as a radiotracer in studies of the mevalonate (MVA) and methylerythritol phosphate (MEP) pathways to elucidate biosynthetic routes.
• Enzyme Kinetics & Inhibition Studies: Employed in assays to determine the activity of enzymes such as farnesyl pyrophosphate synthase (FPPS) and geranylgeranyl pyrophosphate synthase (GGPPS), and to screen for potential inhibitors.
• Drug Discovery Research: Facilitates the study of drugs targeting isoprenoid biosynthesis, which is relevant for developing treatments for cancer, osteoporosis, and infectious diseases like malaria.
• Plant & Microbial Biochemistry: Applied in research on the production of essential oils, carotenoids, gibberellins, and other natural products in plants and microorganisms.
• In Vitro & In Vivo Studies: Suitable for both cell-free enzymatic reactions and tracer studies in cell cultures to monitor the incorporation of IPP into downstream isoprenoids.

Basic Information

Product Name	Ipp, [1-14C]
CAS No.	147385-63-5
Molecular Formula	C5H12O7P2 * (¹⁴C labeled at position 1)
Molecular Weight	~246.09 g/mol (unlabeled)
Synonyms	Isopentenyl Pyrophosphate [1-14C]; (14C)IPP; [1-14C]Isopentenyl Diphosphate; 3-Methyl-3-buten-1-yl Diphosphate [1-14C]; δ³-Isopentenyl Pyrophosphate-1-14C; IPP-1-14C; 14C-Labeled Isopentenyl Pyrophosphate; 1-(14C)-Isopentenyl Diphosphate
EINECS	Contact for details

Quality Control

Every batch of Ipp, [1-14C] is manufactured and analyzed under strict quality protocols to ensure high radiochemical purity and specific activity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing specific activity, radiochemical purity (by HPLC), chemical purity, and solvent composition are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at ≤ -20°C or as recommended on the specific product label or COA. The product is light-sensitive (store away from light). Allow to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Solution (colorless to faint yellow)
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Radiochemical Purity (HPLC)	≥ 95%
Chemical Purity (HPLC)	≥ 90%
Concentration	Contact for details
Solvent	Aqueous buffer or ethanol/water mixture

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.