Description

((1S,4R)-4-(6-Amino-9H-Purin-9-Yl)Cyclopent-2-Enyl)Methanol is a high-purity nucleoside analog building block of significant importance in advanced pharmaceutical research and development. This compound serves as a critical intermediate in the synthesis of novel antiviral and anticancer therapeutics, particularly in the development of modified nucleoside reverse transcriptase inhibitors. It is essential for R&D teams and process chemists in the pharmaceutical and biotechnology industries who require reliable, high-quality building blocks for complex synthetic routes.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of potent antiviral drugs, including nucleoside analogs targeting viral polymerases.
• Antiviral Drug Development: Critical for research into new treatments for viral infections, leveraging its modified purine and cyclopentenyl structure.
• Oncology Research: Used in the development of chemotherapeutic agents that act as antimetabolites or chain terminators in DNA synthesis.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to understand nucleotide metabolism and related pathways.
• Process Chemistry & Scale-Up: Serves as a validated starting material for the GMP-compliant production of active pharmaceutical ingredients (APIs).
• Proteomics & Molecular Biology: Can be utilized in the synthesis of labeled probes or modified nucleotides for diagnostic and research applications.

Basic Information

Product Name	((1S,4R)-4-(6-Amino-9H-Purin-9-Yl)Cyclopent-2-Enyl)Methanol
CAS No.	147332-45-4
Molecular Formula	C11H13N5O
Molecular Weight	231.25 g/mol
Synonyms	(1S,4R)-4-(6-Amino-9H-purin-9-yl)-2-cyclopenten-1-ylmethanol; (-)-Carbovir Intermediate; (1S-cis)-4-(6-Amino-9H-purin-9-yl)-2-cyclopentene-1-methanol; Cyclopentenylmethanol, 4-(6-amino-9H-purin-9-yl)-, (1S,4R)-; 9-[(1S,4R)-4-(Hydroxymethyl)-2-cyclopenten-1-yl]-9H-purin-6-amine; Abacavir Intermediate; Carbocyclic Nucleoside Intermediate
EINECS	Contact for details

Quality Control

Our ((1S,4R)-4-(6-Amino-9H-Purin-9-Yl)Cyclopent-2-Enyl)Methanol is manufactured under strict quality control protocols to ensure it meets the stringent requirements for pharmaceutical intermediates. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to relevant industry standards and our quality systems are designed to support regulatory filings. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.