Description

(R)-Boropro-(+)-Pinanediol-Hcl CAS NO 147208-69-3 is a high-purity, chiral organoboron reagent, specifically the hydrochloride salt of the pinanediol ester of (R)-boroproline. This compound is a critical building block in asymmetric synthesis, valued for its ability to introduce a proline-derived chiral auxiliary with high stereochemical fidelity. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and fine chemical industries for the synthesis of novel active pharmaceutical ingredients (APIs) and complex organic molecules.

Application

• Asymmetric Synthesis: Key chiral intermediate for constructing complex molecules with defined stereocenters.
• Pharmaceutical Research: Used in the development and scale-up of novel APIs, particularly those requiring proline or pyrrolidine motifs.
• Peptidomimetics: Serves as a crucial building block for creating peptide analogs and mimetics with enhanced stability or biological activity.
• Catalyst and Ligand Preparation: Employed in the synthesis of chiral catalysts and ligands for transition metal-catalyzed reactions.
• Methodology Development: A standard reagent in academic and industrial labs for developing new boron-mediated asymmetric transformations.
• Process Chemistry: Integrated into optimized manufacturing routes for chiral drugs, ensuring high enantiomeric purity.

Basic Information

Product Name	(R)-Boropro-(+)-Pinanediol-Hcl
CAS No.	147208-69-3
Molecular Formula	C₁₅H₂₆BClNO₂
Molecular Weight	289.64 g/mol
Synonyms	(R)-1-[(1S,2S,3R,5S)-2,6,6-Trimethylbicyclo[3.1.1]heptan-3-yl] 2-(chlorodihydroboranyl)-1,2-pyrrolidinedicarboxylate; (R)-Boroproline Pinanediol Ester Hydrochloride; (R)-BoroPro-((+)-Pinanediol) HCl; (R)-α-Amino boronic acid pinanediol ester hydrochloride (proline derivative); L-Boroproline pinanediol ester hydrochloride; (R)-Prolineboronic acid pinanediol ester HCl
EINECS	Contact for details

Quality Control

Every batch of (R)-Boropro-(+)-Pinanediol-Hcl is produced under strict quality management protocols. We guarantee high chiral purity and chemical integrity, with specifications typically meeting or exceeding the requirements for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing key parameters such as assay, enantiomeric excess, and impurity profile. Our quality assurance system ensures traceability and consistency for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep the container sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.