Description

(S)-Tenofovir CAS NO 147127-19-3 is the active pharmaceutical ingredient (API) form of the potent nucleotide reverse transcriptase inhibitor, tenofovir. This high-purity enantiomer is critical for ensuring the efficacy and safety of antiviral medications. It is an essential raw material for pharmaceutical manufacturers developing treatments for HIV and chronic Hepatitis B infections.

Application

• Active Pharmaceutical Ingredient (API) in antiviral drug formulations.
• Key Intermediate for the synthesis of Tenofovir Disoproxil Fumarate (TDF) and Tenofovir Alafenamide (TAF).
• Research and development of novel nucleotide analog therapeutics.
• Manufacturing of fixed-dose combination (FDC) antiretroviral drugs.
• Production of generic antiviral medications for global health programs.
• Reference standard for quality control and analytical testing in pharmaceutical labs.

Basic Information

Item	Details
Product Name	(S)-Tenofovir
CAS No.	147127-19-3
Molecular Formula	C9H14N5O4P
Molecular Weight	287.21 g/mol
Synonyms	(R)-9-(2-Phosphonomethoxypropyl)adenine; PMPA; (R)-PMPA; GS-1278; (R)-[[2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic acid; (R)-Tenofovir; (S)-Tenofovir (enantiomer); Tenofovir free acid
EINECS	Contact for details

Quality Control

Our (S)-Tenofovir is manufactured under strict quality systems. We provide material that meets or exceeds pharmaceutical-grade standards, with comprehensive testing to ensure identity, purity, and potency. A detailed Certificate of Analysis (COA) is supplied with each batch, documenting compliance with in-house specifications aligned with ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Optical Rotation	[α]20/D: Specific range provided on COA
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.